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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Pierre Bel Lassen 1, 2 Trine Nielsen 3 Per-Olof Bergh 4 Christine Rouault 1 Sébastien André 1 Florian Marquet 1 Fabrizio Andreelli 1 Joe-Elie Salem 5 Karen Assmann 1 Jean-Philippe Bastard 6 Sofia Forslund 7, 8, 9 Emmanuelle Le Chatelier 10 Gwen Falony 11 Nicolas Pons 10 Edi Prifti 12, 13 Benoit Quinquis 10 Hugo Roume 10 Sara Vieira-Silva 11 Tue Hansen 3 Helle Krogh Pedersen 3 Christian Lewinter 3 Nadja Sønderskov 3 Henrik Vestergaard 3 Jeroen Raes 10, 11 Jens Nielsen 14 Peer Bork 15 S. Dusko Ehrlich 10 Oluf Pedersen 3 Judith Aron-Wisneswky 1, 2 Karine Clément 1, 2 Fredrik Bäckhed 3, 4 Antonio Molinaro 4 Pierre Lassen Marcus Henricsson 4 Hao Wu 4 Solia Adriouch 1 Eugeni Belda 1, 12 Rima Chakaroun 16 Trine Nielse 3 Christine Bergh Sébastien Rouault Florian Andr Fabrizio Marquet Joe-Elie Andreelli Karen Salem Jean-Philippe Assmann Sofia Bastard Emmanuelle Forslund Gwen Le Chatelier Nicolas Falon Edi Pons Benoit Prift Hugo Quinquis Sara Roume Tue Vieira-Silv Krogh Hansen Christian Pedersen Nadja Lewinter Metacardis The Lars Køber 3 Henrik Vestergaar Torben Hansen 3 Jean-Daniel Zucker 13 Pilar Galan 17 Marc-Emmanuel Dumas 18, 19 Jeroen Rae 10 Jean-Michel Oppert 20 Ivica Letunic 21 Jens Nielse S Ehrlic 10 Michael Stumvoll 16 Oluf Pederse Judith Aron-Wisnewsky Karine Clément * Fredrik Bäckhe *
* Corresponding author
17 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
Université Sorbonne Paris Nord, CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
Abstract : Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
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Submitted on : Tuesday, January 12, 2021 - 10:30:16 AM
Last modification on : Saturday, July 3, 2021 - 12:28:58 AM

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Pierre Bel Lassen, Trine Nielsen, Per-Olof Bergh, Christine Rouault, Sébastien André, et al.. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩. ⟨hal-03041270v2⟩

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