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Journal articles

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Pierre Bel Lassen ^{1, 2} Trine Nielsen ³ Per-Olof Bergh ⁴ Christine Rouault ¹ Sébastien André ¹ Florian Marquet ¹ Fabrizio Andreelli ¹ Joe-Elie Salem ⁵ Karen Assmann ¹ Jean-Philippe Bastard ⁶ Sofia Forslund ^{7, 8, 9} Emmanuelle Le Chatelier ¹⁰ Gwen Falony ¹¹ Nicolas Pons ¹⁰ Edi Prifti ^{12, 13} Benoit Quinquis ¹⁰ Hugo Roume ¹⁰ Sara Vieira-Silva ¹¹ Tue Hansen ³ Helle Krogh Pedersen ³ Christian Lewinter ³ Nadja Sønderskov ³ Henrik Vestergaard ³ Jeroen Raes ^{10, 11} Jens Nielsen ¹⁴ Peer Bork ¹⁵ S. Dusko Ehrlich ¹⁰ Oluf Pedersen ³ Judith Aron-Wisneswky ^{1, 2} Karine Clément ^{1, 2} Fredrik Bäckhed ^{3, 4} Antonio Molinaro ⁴ Pierre Bel Lassen Marcus Henricsson ⁴ Hao Wu ⁴ Solia Adriouch ¹ Eugeni Belda ^{1, 12} Rima Chakaroun ¹⁶ Trine Nielse ³ Christine Bergh Sébastien Rouault Florian Andr Fabrizio Marquet Joe-Elie Andreelli Karen Salem Jean-Philippe Assmann Sofia Bastard Emmanuelle Forslund Gwen Le Chatelier Nicolas Falon Edi Pons Benoit Prift Hugo Quinquis Sara Roume Tue H Vieira-Silv Krogh Hansen Christian Pedersen Nadja B Lewinter Metacardis The Lars Køber ³ Henrik Vestergaar Torben Hansen ³ Jean-Daniel Zucker ¹³ Pilar Galan ¹⁷ Marc-Emmanuel Dumas ^{18, 19} Jeroen Rae ¹⁰ Jean-Michel Oppert ²⁰ Ivica Letunic ²¹ Jens Nielse S Dusko Ehrlic ¹⁰ Michael Stumvoll ¹⁶ Oluf Pederse Judith Aron-Wisnewsky Karine Clément ^* Fredrik Bäckhe ^*

* Corresponding author

1 Nutriomics - Nutrition et obésités: approches systémiques (UMR-S 1269)

2 CRNH-IDF - Centre de Recherche en Nutrition Humaine d'Ile-de-France

3 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research

4 Sahlgrenska Academy at University of Gothenburg [Göteborg]

5 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)

6 CHU Tenon [AP-HP]

7 Experimental and Clinical Research Center [Berlin, Germany]

8 MDC - Max Delbrück Center for Molecular Medicine [Berlin]

9 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]

10 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé

11 Rega Institute for Medical Research [Leuven, België]

12 Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [IHU ICAN]

13 UMMISCO - Unité de modélisation mathématique et informatique des systèmes complexes [Bondy]

14 Chalmers University of Technology [Göteborg]

15 EMBL - European Molecular Biology Laboratory [Heidelberg]

16 Universität Leipzig [Leipzig]

17 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle

Université Sorbonne Paris Nord, CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité

18 NHLI - National Heart and Lung Institute [London]

19 Imperial College London

20 Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF)

21 Biobyte Solutions GMBH

Abstract : Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

Document type :

Journal articles

Domain :

Chemical Sciences

Life Sciences [q-bio]

Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03041270
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Submitted on : Tuesday, January 12, 2021 - 10:30:16 AM
Last modification on : Friday, May 20, 2022 - 11:06:55 AM