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Journal Articles Nature Communications Year : 2020

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

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Pierre Bel Lassen
  • Function : Author
Christine Bergh
  • Function : Author
Sébastien Rouault
  • Function : Author
Florian Andr
  • Function : Author
Fabrizio Marquet
  • Function : Author
Joe-Elie Andreelli
  • Function : Author
Karen Salem
  • Function : Author
Jean-Philippe Assmann
  • Function : Author
Sofia Bastard
  • Function : Author
Emmanuelle Forslund
  • Function : Author
Gwen Le Chatelier
  • Function : Author
Nicolas Falon
  • Function : Author
Edi Pons
  • Function : Author
Benoit Prift
  • Function : Author
Hugo Quinquis
  • Function : Author
Sara Roume
  • Function : Author
Tue H Vieira-Silv
  • Function : Author
Krogh Hansen
  • Function : Author
Christian Pedersen
  • Function : Author
Nadja B Lewinter
  • Function : Author
Metacardis The
  • Function : Author
Henrik Vestergaar
  • Function : Author
Jens Nielse
  • Function : Author
Oluf Pederse
  • Function : Author
Judith Aron-Wisnewsky
  • Function : Author
Karine Clément
  • Function : Correspondent author
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Fredrik Bäckhe
  • Function : Correspondent author
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Abstract

Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
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Dates and versions

hal-03041270 , version 1 (07-12-2020)
hal-03041270 , version 2 (12-01-2021)

Licence

Attribution - CC BY 4.0

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Pierre Bel Lassen, Trine Nielsen, Per-Olof Bergh, Christine Rouault, Sébastien André, et al.. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩. ⟨hal-03041270v2⟩
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