Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
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Pierre Bel Lassen
- Function : relator_co_first_author
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- ORCID : 0000-0002-8085-2881
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Trine Nielsen
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Joe-Elie Salem
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- IdRef : 160947227
Nicolas Pons
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- PersonId : 1206296
Edi Prifti
- Function : Author
- PersonId : 1151183
- IdHAL : edi-prifti
Benoit Quinquis
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- PersonId : 1207439
Hugo Roume
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- PersonId : 1207440
Sara Vieira-Silva
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- PersonId : 775753
- ORCID : 0000-0002-4616-7602
Tue Hansen
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- PersonId : 804421
- ORCID : 0000-0001-5948-8993
Henrik Vestergaard
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Jeroen Raes
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Jens Nielsen
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S. Dusko Ehrlich
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Oluf Pedersen
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- ORCID : 0000-0002-3321-3972
Karine Clément
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- ORCID : 0000-0002-2489-3355
Fredrik Bäckhed
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Antonio Molinaro
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Pierre Bel Lassen
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Marcus Henricsson
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- PersonId : 804423
- ORCID : 0000-0002-4202-0339
Hao Wu
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- PersonId : 19225
- IdHAL : hao-wu
- ORCID : 0000-0003-0342-4709
Solia Adriouch
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- PersonId : 1203557
Christine Bergh
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Sébastien Rouault
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Florian Andr
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Fabrizio Marquet
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Joe-Elie Andreelli
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Karen Salem
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Jean-Philippe Assmann
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Sofia Bastard
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Emmanuelle Forslund
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Gwen Le Chatelier
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Nicolas Falon
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Edi Pons
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Benoit Prift
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Hugo Quinquis
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Sara Roume
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Tue H Vieira-Silv
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Krogh Hansen
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Christian Pedersen
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Nadja B Lewinter
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Metacardis The
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Lars Køber
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- ORCID : 0000-0002-6635-1466
Henrik Vestergaar
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Torben Hansen
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- ORCID : 0000-0001-8748-3831
Jean-Daniel Zucker
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- IdHAL : jean-daniel-zucker
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Pilar Galan
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Marc-Emmanuel Dumas
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- IdHAL : marc-emmanuel-dumas
- ORCID : 0000-0001-9523-7024
Jean-Michel Oppert
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- PersonId : 763562
- ORCID : 0000-0003-0324-4820
Jens Nielse
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Oluf Pederse
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Judith Aron-Wisnewsky
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Karine Clément
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Fredrik Bäckhe
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Abstract
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.