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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Antonio Molinaro 1 Pierre Bel Lassen 2, 3 Marcus Henricsson 1 Hao Wu 1 Solia Adriouch 2 Eugeni Belda 2, 4 Rima Chakaroun 5 Trine Nielsen 6 Per-Olof Bergh 1 Christine Rouault 2 Sébastien André 2 Florian Marquet 2 Fabrizio Andreelli 2 Joe-Elie Salem 7 Karen Assmann 2 Jean-Philippe Bastard 8 Sofia Forslund 9, 10, 11 Emmanuelle Le Chatelier 12 Gwen Falony 13 Nicolas Pons 12 Edi Prifti 4, 14 Benoit Quinquis 12 Hugo Roume 12 Sara Vieira-Silva 13 Tue Hansen 6 Helle Krogh Pedersen 6 Christian Lewinter 6 Nadja Sønderskov 6 Lars Køber 6 Henrik Vestergaard 6 Torben Hansen 6 Jean-Daniel Zucker 14 Pilar Galan 15 Marc-Emmanuel Dumas 16, 17 Jeroen Raes 12, 13 Jean-Michel Oppert 18 Ivica Letunic 19 Jens Nielsen 20 Peer Bork 21 S. Dusko Ehrlich 12 Michael Stumvoll 5 Oluf Pedersen 6 Judith Aron-Wisneswky 2, 3 Karine Clément 2, 3 Fredrik Bäckhed 6, 1
Abstract : Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
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Contributor : Marc-Emmanuel Dumas <>
Submitted on : Monday, December 7, 2020 - 12:35:56 PM
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Antonio Molinaro, Pierre Bel Lassen, Marcus Henricsson, Hao Wu, Solia Adriouch, et al.. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩. ⟨hal-03041270v1⟩



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