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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Antonio Molinaro 1 Pierre Bel Lassen 2, 3 Marcus Henricsson 1 Hao Wu 1 Solia Adriouch 2 Eugeni Belda 2, 4 Rima Chakaroun 5 Trine Nielsen 6 Per-Olof Bergh 1 Christine Rouault 2 Sébastien André 2 Florian Marquet 2 Fabrizio Andreelli 2 Joe-Elie Salem 7 Karen Assmann 2 Jean-Philippe Bastard 8 Sofia Forslund 9, 10, 11 Emmanuelle Le Chatelier 12 Gwen Falony 13 Nicolas Pons 12 Edi Prifti 4, 14 Benoit Quinquis 12 Hugo Roume 12 Sara Vieira-Silva 13 Tue Hansen 6 Helle Krogh Pedersen 6 Christian Lewinter 6 Nadja Sønderskov 6 Lars Køber 6 Henrik Vestergaard 6 Torben Hansen 6 Jean-Daniel Zucker 14 Pilar Galan 15 Marc-Emmanuel Dumas 16, 17 Jeroen Raes 12, 13 Jean-Michel Oppert 18 Ivica Letunic 19 Jens Nielsen 20 Peer Bork 21 S. Dusko Ehrlich 12 Michael Stumvoll 5 Oluf Pedersen 6 Judith Aron-Wisneswky 2, 3 Karine Clément 2, 3 Fredrik Bäckhed 6, 1
1 Sahlgrenska Academy at University of Gothenburg [Göteborg]
2 UMR-S 1269 INSERM - Sorbonne Université - Nutrition et obésités: approches systémiques (nutriomics)
3 CRNH-IDF - Centre de Recherche en Nutrition Humaine d'Ile-de-France
4 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition
5 Universität Leipzig [Leipzig]
6 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
7 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
8 AP-HP Hôpital Tenon [Paris]
9 Experimental and Clinical Research Center [Berlin, Germany]
10 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
11 Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin
12 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
13 Rega Institute for Medical Research [Leuven, België]
14 UMMISCO - Unité de modélisation mathématique et informatique des systèmes complexes [Bondy]
15 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
16 NHLI - National Heart and Lung Institute [London]
17 Imperial College London
18 Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF)
19 Auteur indépendant
20 Chalmers University of Technology [Göteborg]
21 EMBL - European Molecular Biology Laboratory [Heidelberg]
Abstract : Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
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https://hal-cnrs.archives-ouvertes.fr/hal-03041270
Contributor : Marc-Emmanuel Dumas <>
Submitted on : Monday, December 7, 2020 - 12:35:56 PM
Last modification on : Saturday, January 16, 2021 - 3:19:50 AM

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Antonio Molinaro, Pierre Bel Lassen, Marcus Henricsson, Hao Wu, Solia Adriouch, et al.. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩. ⟨hal-03041270v1⟩

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