4-Substituted-1,2,3-triazolo nucleotide analogues as CD73 inhibitors, their synthesis, in vitro screening, kinetic and in silico studies

Rayane Ghoteimi , Abdennour Braka , Céline Rodriguez , Emeline Cros-Perrial , Van Tai Nguyen , Jean-Pierre Uttaro , Christophe Mathé , Laurent Chaloin (1) , Christine Ménétrier-Caux , Lars Petter Jordheim , Suzanne Peyrottes

1 IRIM - Institut de Recherche en Infectiologie de Montpellier

Domaines: Chemo-informatique; Biologie structurale [q-bio.BM]

Rayane Ghoteimi, Abdennour Braka, Céline Rodriguez, Emeline Cros-Perrial, Van Tai Nguyen, et al.. 4-Substituted-1,2,3-triazolo nucleotide analogues as CD73 inhibitors, their synthesis, in vitro screening, kinetic and in silico studies. Bioorganic Chemistry, 2021, 107, pp.104577. ⟨10.1016/j.bioorg.2020.104577⟩. ⟨hal-03407446v1⟩