Electrophilic Fluorination of Silyl Dienol Ethers: a General and Selective Access to γ‐Fluoro Enals

Yang Li (1) , Marina Briand (1) , Karinne Miqueu (2) , Elsa Anselmi (1) , Emmanuel Magnier (1) , Guillaume Dagousset

1 ILV - Institut Lavoisier de Versailles
2 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

We describe the direct synthesis of γ‐fluoro enals from the corresponding silyl dienol ethers. This simple process operates under mild conditions and is compatible with a wide range of functionalities. The high γ regioselectivity of this protocol was rationalized by means of theoretical calculations.

Domaines: Chimie

Yang Li, Marina Briand, Karinne Miqueu, Elsa Anselmi, Emmanuel Magnier, et al.. Electrophilic Fluorination of Silyl Dienol Ethers: a General and Selective Access to γ‐Fluoro Enals. Chemistry - A European Journal, 2024, 30 (10), pp.e202303545. ⟨10.1002/chem.202303545⟩. ⟨hal-04404468⟩