Discovery of N -β- l -Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB

Patrycja Mała (1) , Eike Siebs (1) , Joscha Meiers (1) , Katharina Rox (2) , Annabelle Varrot (3) , Anne Imberty (3) , Alexander Titz (1)

1 HIPS - Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland
2 DZIF - 4Deutsches Zentrum für Infektionsforschung
3 CERMAV - Centre de Recherches sur les Macromolécules Végétales

Mots clés: Lectin; carbohydrates; fucose; glycomimetics; LecB 2

Domaines: Chimie

Patrycja Mała, Eike Siebs, Joscha Meiers, Katharina Rox, Annabelle Varrot, et al.. Discovery of N -β- l -Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB. Journal of Medicinal Chemistry, 2022, 65 (20), pp.14180-14200. ⟨10.1021/acs.jmedchem.2c01373⟩. ⟨hal-03834673⟩