Skip to Main content Skip to Navigation
Journal articles

Extracellular AGR3 regulates breast cancer cells migration via Src signaling

Abstract : Human anterior gradient proteins AGR2 and AGR3 are overexpressed in a variety of adenocarcinomas and are often secreted in cancer patients' specimens, which suggests a role for AGR proteins in intra and extracellular compartments. Although these proteins exhibit high sequence homology, AGR2 is predominantly described as a pro-oncogene and a potential prognostic biomarker. However, little is known about the function of AGR3. Therefore, the aim of the present study was to investigate the role of AGR3 in breast cancer. The results demonstrated that breast cancer cells secrete AGR3. Furthermore, it was revealed that extracellular AGR3 (eAGR3) regulates tumor cell adhesion and migration. The current study indicated that the pharmacological and genetic perturbation of Src kinase signaling, through treatment with Dasatinib (protein kinase inhibitor) or investigating cells that express a dominant-negative form of Src, significantly abrogated eAGR3-mediated breast cancer cell migration. Therefore, the results indicated that eAGR3 may control tumor cell migration via activation of Src kinases. The results of the present study indicated that eAGR3 may serve as a microenvironmental signaling molecule in tumor-associated processes.
Document type :
Journal articles
Complete list of metadatas

Cited literature [42 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02365416
Contributor : Laurent Jonchère <>
Submitted on : Friday, July 10, 2020 - 3:07:20 PM
Last modification on : Tuesday, July 21, 2020 - 2:33:56 PM

File

ol_18_5_4449_PDF.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Joanna Obacz, Lucia Sommerova, Daria Sicari, Michal Durech, Tony Avril, et al.. Extracellular AGR3 regulates breast cancer cells migration via Src signaling. Oncology Letters, Spandidos Publications, 2019, 18 (5), pp.4449-4456. ⟨10.3892/ol.2019.10849⟩. ⟨hal-02365416⟩

Share

Metrics

Record views

40

Files downloads

44