The Long Non-Coding RNA ANRIL in Cancers

Aymeric Sanchez (1) , Julien Lhuillier (1) , Guillaume Grosjean (2) , Lilia Ayadi (1) , Sylvain Maenner (1)

1 IMOPA - Ingénierie Moléculaire, Cellulaire et Physiopathologie
2 SATT SAYENS [Dijon]

ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome 9p21 region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes, including cell cycle control and proliferation. Dysregulation of ANRIL has been associated with several diseases like cancers and cardiovascular diseases, for instance. Understanding the oncogenic role of ANRIL and its potential as a diagnostic and prognostic biomarker in cancer is crucial. This review provides insights into the regulatory mechanisms and oncogenic significance of the 9p21 locus and ANRIL in cancer.

Mots clés: LncRNA ANRIL 9p21 locus cancer gene regulation epigenetics competitive endogenous RNA; LncRNA; ANRIL; 9p21 locus; cancer; gene regulation; epigenetics; competitive endogenous RNA

Domaines: Sciences du Vivant [q-bio]

Aymeric Sanchez, Julien Lhuillier, Guillaume Grosjean, Lilia Ayadi, Sylvain Maenner. The Long Non-Coding RNA ANRIL in Cancers. Cancers, 2023, 15 (16), pp.4160. ⟨10.3390/cancers15164160⟩. ⟨hal-04566182⟩