Cullin 3, a cellular scripter of the non-proteolytic ubiquitin code, Semin Cell Dev Biol, issue.18, pp.30033-30041, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02370983
Radislav Sedlacek and Izabela Sumara: Deubiquitinating enzyme UCHL3 controls genome segregation in human cells ,
Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis ,
, EMBO Reports
, France Poster presentation: Cell Signaling and Cancer Therapy, Chromosome segregation and structure: Cold Spring Harbor, 2017, USA Poster presentation: LMB-IGBMC Symposium, 2018.
Ubiquitin modifications, Cell Res, vol.26, pp.399-422, 2016. ,
TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases, BioEssays News Rev. Mol. Cell. Dev. Biol, vol.27, pp.1147-1157, 2005. ,
Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2, Cancer Res, vol.68, pp.5572-5580, 2008. ,
TRIM31 interacts with p52(Shc) and inhibits Src-induced anchorage-independent growth, Biochem. Biophys. Res. Commun, vol.388, pp.422-427, 2009. ,
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin, Nat. Commun, vol.6, p.7299, 2015. ,
TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells, J. Cell Sci, vol.125, pp.1544-1555, 2012. ,
PML protein isoforms and the RBCC/TRIM motif, Oncogene, vol.20, pp.7223-7233, 2001. ,
TRIM E3 ligases interfere with early and late stages of the retroviral life cycle, PLoS Pathog, vol.4, p.16, 2008. ,
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys, Nature, vol.427, pp.848-853, 2004. ,
Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy, Circ. Res, vol.111, pp.907-919, 2012. ,
The M694V variant of the familial Mediterranean fever gene is associated with sporadic early-onset Alzheimer's disease in an Italian population sample, Dement. Geriatr. Cogn. Disord, vol.23, pp.55-59, 2007. ,
MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation, Nat. Genet, vol.29, pp.287-294, 2001. ,
TRIM24 links a non-canonical histone signature to breast cancer, Nature, vol.468, pp.927-932, 2010. ,
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.8212-8217, 2011. ,
Mitotic kinases as regulators of cell division and its checkpoints, Nat. Rev. Mol. Cell Biol, vol.2, p.21, 2001. ,
Breaking the chains: structure and function of the deubiquitinases, Nat. Rev. Mol. Cell Biol, vol.10, pp.550-563, 2009. ,
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination, Genes Dev, vol.30, pp.2581-2595, 2016. ,
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis, Cell Rep, vol.23, pp.3352-3365, 2018. ,
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores, Nat. Commun, vol.10, 2019. ,
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E, Cell, vol.142, pp.444-455, 2010. ,
Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells, Proc. Natl. Acad. Sci. U. S. A, vol.72, pp.11-15, 1975. ,
Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells, Nat. Methods, vol.11, pp.319-324, 2014. ,
Regulatory mechanisms involved in the control of ubiquitin homeostasis, J. Biochem. (Tokyo), vol.147, pp.793-798, 2010. ,
The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors, Sci. Rep, vol.5, p.12836, 2015. ,
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1, Proc. Natl. Acad. Sci. U. S. A, vol.88, pp.258-262, 1991. ,
E1-L2 Activates Both Ubiquitin and FAT10, Mol. Cell, vol.27, pp.1014-1023, 2007. ,
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging, Nature, vol.447, pp.1135-1138, 2007. ,
E2 enzymes: more than just middle men, Cell Res, vol.26, pp.423-440, 2016. ,
Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling, PLoS ONE, vol.3, 2008. ,
New insights into ubiquitin E3 ligase mechanism, Nat. Struct. Mol. Biol, vol.21, pp.301-307, 2014. ,
A Conserved Cysteine Is Essential for Pex4p-dependent Ubiquitination of the Peroxisomal Import Receptor Pex5p, J. Biol. Chem, vol.282, pp.22534-22543, 2007. ,
KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant, PLOS ONE, vol.10, p.145654, 2015. ,
Non-canonical ubiquitylation of the proneural protein Ngn2 occurs in both Xenopus embryos and mammalian cells, Biochem. Biophys. Res. Commun, vol.400, pp.655-660, 2010. ,
Ube2W conjugates ubiquitin to ?-amino groups of protein N-termini, Biochem. J, vol.453, pp.137-145, 2013. ,
Mixed-linkage ubiquitin chains send mixed messages, Struct. Lond. Engl, vol.21, pp.727-740, 1993. ,
Enhanced protein degradation by branched ubiquitin chains, Cell, vol.157, pp.910-921, 2014. ,
Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome-wide turnover, EMBO Rep, vol.16, pp.1131-1144, 2015. ,
Ubiquitin is phosphorylated by PINK1 to activate parkin, Nature, vol.510, pp.162-166, 2014. ,
Ubiquitin acetylation inhibits polyubiquitin chain elongation, EMBO Rep, vol.16, pp.192-201, 2015. ,
Ubiquitination independent of E1 and E2 enzymes by bacterial effectors, Nature, vol.533, p.120, 2016. ,
Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control, Sci. Signal, vol.4, pp.4-4, 2011. ,
Role of ubiquitin-and Ubl-binding proteins in cell signaling, Curr. Opin. Cell Biol, vol.19, pp.199-205, 2007. ,
Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions, Annu. Rev. Biochem, vol.81, pp.291-322, 2012. ,
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination, Mol. Cell. Biol, vol.15, pp.1265-1273, 1995. ,
A multiubiquitin chain is confined to specific lysine in a targeted shortlived protein, Science, vol.243, pp.1576-1583, 1989. ,
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors, Cell Cycle Georget. Tex, vol.9, pp.2342-2352, 2010. ,
SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis, Exp. Cell Res, vol.315, pp.1832-1839, 2009. ,
Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells, J. Cell Biol, vol.164, pp.233-241, 2004. ,
Visualizing K48 Ubiquitination during Presynaptic Formation By Ubiquitination-Induced Fluorescence Complementation (UiFC), Front. Mol. Neurosci, vol.9, p.43, 2016. ,
Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation, Nat. Commun, vol.9, p.4648, 2018. ,
K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites, Cell Res, vol.22, pp.1221-1223, 2012. ,
Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex, Cell, vol.133, pp.653-665, 2008. ,
K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody, Mol. Cell, vol.39, pp.477-484, 2010. ,
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease, J. Biol. Chem, vol.286, pp.10457-10465, 2011. ,
Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors, Cell, vol.130, pp.349-362, 2007. ,
Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF-?B Precursor, Mol. Cell, vol.33, pp.496-504, 2009. ,
APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1, Nat. Cell Biol, vol.14, pp.168-176, 2012. ,
Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules, EMBO J, vol.25, pp.1635-1645, 2006. ,
Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor, J. Lipid Res, vol.54, pp.1410-1420, 2013. ,
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy, Proc. Natl. Acad. Sci, vol.112, pp.6637-6642, 2015. ,
A role for ubiquitin in the spliceosome assembly pathway, Nat. Struct. Mol. Biol, vol.15, pp.444-451, 2008. ,
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain, Cell, vol.102, pp.67-76, 2000. ,
K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway, J. Cell Biol, vol.185, pp.493-502, 2009. ,
The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane, Mol. Biol. Cell, vol.23, pp.1343-1353, 2012. ,
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain, Cell, vol.103, pp.351-361, 2000. ,
The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation, Cell, vol.123, pp.409-421, 2005. ,
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair, Cell, vol.96, pp.645-653, 1999. ,
K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair, Sci. Signal, vol.11, 2018. ,
RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites, Science, vol.316, pp.1198-1202, 2007. ,
The demographics of the ubiquitin system, Trends Cell Biol, vol.25, pp.417-426, 2015. ,
The Cul3-KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis, J. Cell Biol, vol.187, pp.791-800, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02371103
Monoubiquitination of Filamin B Regulates Vascular Endothelial Growth Factor-Mediated Trafficking of Histone Deacetylase 7, Mol. Cell. Biol, vol.33, pp.1546-1560, 2013. ,
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors, Sci. Signal, vol.4, p.13, 2011. ,
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II, Cell, vol.125, pp.703-717, 2006. ,
Monoubiquitination of H2AX protein regulates DNA damage response signaling, J. Biol. Chem, vol.286, pp.28599-28607, 2011. ,
Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy, Nucleic Acids Res, vol.45, pp.1144-1158, 2017. ,
Linear ubiquitin chains: enzymes, mechanisms and biology, Open Biol, vol.7, 2017. ,
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation, Cell, vol.136, pp.1098-1109, 2009. ,
Involvement of linear polyubiquitylation of NEMO in NF-?B activation, Nat. Cell Biol, vol.11, pp.123-132, 2009. ,
Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFainduced apoptosis, J. Biol. Chem. jbc.RA118, p.5449, 2018. ,
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L, Nat. Commun, vol.9, p.3910, 2018. ,
A Genomic and Functional Inventory of Deubiquitinating Enzymes, Cell, vol.123, pp.773-786, 2005. ,
Mechanisms of Deubiquitinase Specificity and Regulation, Annu. Rev. Biochem, vol.86, pp.159-192, 2017. ,
MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes, Mol. Cell, vol.63, pp.146-155, 2016. ,
Identification of a novel isopeptidase with dual specificity for ubiquitin-and NEDD8-conjugated proteins, J. Biol. Chem, vol.275, pp.14212-14216, 2000. ,
Cleavage of the C-Terminus of NEDD8 by UCH-L3, Biochem. Biophys. Res. Commun, vol.251, pp.688-692, 1998. ,
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1, Science, vol.298, pp.608-611, 2002. ,
The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types, Chem. Biol, vol.18, pp.1550-1561, 2011. ,
OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis, Cell, vol.154, pp.169-184, 2013. ,
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne, Nat. Struct. Mol. Biol, vol.17, pp.939-947, 2010. ,
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase, Nat. Chem. Biol, vol.6, pp.750-757, 2010. ,
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains, Nature, vol.455, pp.358-362, 2008. ,
AMSH is an endosome-associated ubiquitin isopeptidase, J. Cell Biol, vol.166, pp.487-492, 2004. ,
A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains, EMBO Rep, vol.18, pp.392-402, 2017. ,
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis, Cell Rep, vol.23, pp.3352-3365, 2018. ,
Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21, EMBO Rep, vol.12, pp.350-357, 2011. ,
Assembly, analysis and architecture of atypical ubiquitin chains, Nat. Struct. Mol. Biol, vol.20, pp.555-565, 2013. ,
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis, EMBO J, vol.34, pp.307-325, 2015. ,
USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites, Nature, vol.532, pp.398-401, 2016. ,
Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome, Science, vol.298, pp.611-615, 2002. ,
The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks, Cell Cycle, vol.17, pp.1413-1424, 2018. ,
ATR signalling: more than meeting at the fork, Biochem. J, vol.436, pp.527-536, 2011. ,
USP10 regulates p53 localization and stability by deubiquitinating p53, Cell, vol.140, pp.384-396, 2010. ,
USP11 regulates p53 stability by deubiquitinating p53, J. Zhejiang Univ. Sci. B, vol.15, pp.1032-1038, 2014. ,
, OTUD5 regulates p53 stability by deubiquitinating p53, vol.8, p.77682, 2013.
, , 1882.
, SCANNING ELECTRON MICROSCOPY OF HUMAN METAPHASE CHROMOSOMES, vol.14, 1982.
A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro, Cell, vol.79, pp.449-458, 1994. ,
Mitotic Chromosome Mechanics: How Cells Segregate Their Genome, Trends Cell Biol, 2019. ,
Phosphorylation and activation of 13S condensin by Cdc2 in vitro, Science, vol.282, pp.487-490, 1998. ,
The condensin complex is a mechanochemical motor that translocates along DNA, Science, vol.358, pp.672-676, 2017. ,
A pathway for mitotic chromosome formation, Science, vol.359, p.6135, 2018. ,
Mitotic Chromosome Structure: Reproducibility of Folding and Symmetry between Sister Chromatids, Biophys. J, vol.96, pp.1617-1628, 2009. ,
Condensin Is Required for Nonhistone Protein Assembly and Structural Integrity of Vertebrate Mitotic Chromosomes, Dev. Cell, vol.5, pp.323-336, 2003. ,
Topoisomerase II inhibition prevents anaphase chromatid segregation in mammalian cells independently of the generation of DNA strand breaks, J. Cell Sci, vol.105, pp.563-569, 1993. ,
Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis, Genes Dev, vol.16, pp.3004-3016, 2002. ,
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase, Mol. Cell, vol.9, pp.515-525, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-02371160
Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion, Curr. Biol, vol.28, pp.2837-2844, 2018. ,
Holocentromeres are dispersed point centromeres localized at transcription factor hotspots, vol.3, p.2025, 2014. ,
Elastic and Rigidified CENP-A Nucleosomes govern Centromeric Chromatin Plasticity, p.392787, 2018. ,
The structure of the cold-stable kinetochore fiber in metaphase PtK1 cells, Chromosoma, vol.84, pp.145-158, 1981. ,
Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice, Proc. Natl. Acad. Sci. U. S. A, vol.97, pp.1148-1153, 2000. ,
Dual recognition of CENP-A nucleosomes is required for centromere assembly, J. Cell Biol, vol.189, pp.1143-1155, 2010. ,
CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore, Cell, vol.135, pp.1039-1052, 2008. ,
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore, Cell, vol.127, pp.983-997, 2006. ,
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment, Nat. Struct. Mol. Biol, vol.14, pp.54-59, 2007. ,
Unstable Kinetochore-Microtubule Capture and Chromosomal Instability Following Deletion of CENP-E, Dev. Cell, vol.3, pp.351-365, 2002. ,
Depletion of Centromeric MCAK Leads to Chromosome Congression and Segregation Defects Due to Improper Kinetochore Attachments, Mol. Biol. Cell, vol.15, pp.1146-1159, 2004. ,
Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material, Nat. Cell Biol, vol.14, pp.1148-1158, 2012. ,
Microtubule nucleation by ?-tubulin-containing rings in the centrosome, Nature, vol.378, pp.638-640, 1995. ,
The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5, Curr. Biol. CB, vol.14, pp.1783-1788, 2004. ,
A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging, EMBO J, vol.30, pp.906-919, 2011. ,
Clathrin is required for the function of the mitotic spindle, Nature, vol.434, pp.1152-1157, 2005. ,
The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle, vol.4 ,
Kinetochore fiber formation in animal somatic cells: dueling mechanisms come to a draw, Chromosoma, vol.114, pp.310-318, 2005. ,
Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis, J. Cell Biol, vol.160, pp.671-683, 2003. ,
Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis, J. Cell Biol, vol.167, pp.831-840, 2004. ,
Motor function in interpolar microtubules during metaphase, J. Theor. Biol, vol.370, pp.1-10, 2015. ,
A Homotetrameric Kinesin-5, KLP61F, Bundles Microtubules and Antagonizes Ncd in Motility Assays, Curr. Biol, vol.16, pp.2293-2302, 2006. ,
Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos, Nat. Cell Biol, vol.1, pp.51-54, 1999. ,
Bridging the gap between sister kinetochores, Cell Cycle, vol.15, pp.1169-1170, 2016. ,
Overlap microtubules link sister k-fibres and balance the forces on bioriented kinetochores, Nat. Commun, vol.7, p.10298, 2016. ,
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells, J. Cell Biol, vol.153, pp.517-527, 2001. ,
Examining the link between chromosomal instability and aneuploidy in human cells, J. Cell Biol, vol.180, pp.665-672, 2008. ,
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics, Mol. Cell. Proteomics MCP, vol.15, pp.2448-2461, 2016. ,
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation, Nature, vol.467, pp.719-723, 2010. ,
Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis, Mol. Endocrinol. Baltim. Md, vol.21, pp.726-739, 2007. ,
Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men, Asian J. Androl, vol.17, pp.68-73, 2015. ,
CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage, Cell Cycle Georget. Tex, vol.4, pp.1233-1238, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00317413
Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue, Nat. Commun, vol.9, p.1888, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01863221
Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A, J. Cell Sci, vol.132, 2019. ,
A Complex of Kif18b and MCAK Promotes Microtubule Depolymerization and Is Negatively Regulated by Aurora Kinases, Curr. Biol, vol.21, pp.1356-1365, 2011. ,
Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a, J. Cell Sci, vol.122, pp.1334-1341, 2009. ,
, Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell, vol.131, pp.271-285, 2007.
Chromosomal passengers: the four-dimensional regulation of mitotic events, Chromosoma, vol.113, pp.211-222, 2004. ,
Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin, Science, vol.327, pp.172-177, 2010. ,
A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis, Curr. Biol. CB, vol.21, pp.1061-1069, 2011. ,
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes, J. Cell Sci, vol.120, pp.1245-1255, 2007. ,
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint, J. Cell Biol, vol.161, pp.281-294, 2003. ,
Correcting improper chromosome-spindle attachments during cell division, Nat. Cell Biol, vol.6, pp.232-237, 2004. ,
Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors, Curr. Biol. CB, vol.16, pp.1711-1718, 2006. ,
Aurora B Regulates MCAK at the Mitotic Centromere, Dev. Cell, vol.6, pp.253-268, 2004. ,
Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules, Dev. Cell, vol.36, pp.63-78, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02371072
The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage, Cell, vol.125, pp.85-98, 2006. ,
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis, J. Cell Biol, vol.195, pp.1093-1101, 2011. ,
Plk1 Controls the Nek2A-PP1? Antagonism in Centrosome Disjunction, Curr. Biol, vol.21, pp.1145-1151, 2011. ,
Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1, EMBO J, vol.30, pp.2233-2245, 2011. ,
Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase, Nat. Cell Biol, vol.13, pp.1265-1271, 2011. ,
Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions, Genes Dev, vol.21, pp.2205-2219, 2007. ,
Ubiquitylation-dependent localization of PLK1 in mitosis, Nat. Cell Biol, vol.15, pp.430-439, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-02371100
Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission, J. Cell Biol, vol.191, pp.751-760, 2010. ,
A screen for deubiquitinating enzymes involved in the G2/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability, Cell Cycle, vol.9, pp.3839-3846, 2010. ,
USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase, Cell Death Differ, vol.20, pp.721-731, 2013. ,
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities, Nature, vol.446, pp.876-881, 2007. ,
Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis, J. Cell Biol, vol.210, pp.727-735, 2015. ,
Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNAlevels of aurora B, Cell Cycle Georget. Tex, vol.7, pp.2710-2719, 2008. ,
Chromosome Alignment and Segregation Regulated by Ubiquitination of Survivin, Science, vol.310, pp.1499-1504, 2005. ,
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome, Genes Dev, vol.24, pp.1434-1447, 2010. ,
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1, Mol. Cell, vol.2, pp.163-171, 1998. ,
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin, EMBO J, vol.29, pp.131-144, 2010. ,
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis, J. Cell Sci, vol.121, pp.1325-1333, 2008. ,
Ubiquitin-Mediated Degradation of Aurora Kinases, Front. Oncol, vol.5, 2016. ,
USP35 regulates mitotic progression by modulating the stability of Aurora B, Nat. Commun, vol.9, p.688, 2018. ,
Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly, BMC Biol, vol.17, p.42, 2019. ,
Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment, Sci. Rep, vol.8, p.3888, 2018. ,
Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells, J. Cell Biol, vol.110, pp.81-95, 1990. ,
Traction force on a kinetochore at metaphase acts as a linear function of kinetochore fiber length, J. Cell Biol, vol.93, pp.374-389, 1982. ,
Two different microtubule-based motor activities with opposite polarities in kinetochores, Nature, vol.351, pp.206-211, 1991. ,
Kinetochores moving away from their associated pole do not exert a significant pushing force on the chromosome, J. Cell Biol, vol.135, pp.315-327, 1996. ,
Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence, J. Cell Biol, vol.109, pp.637-652, 1989. ,
Contribution of microtubule growth polarity and flux to spindle assembly and functioning in plant cells, J. Cell Sci, vol.119, pp.3193-3205, 2006. ,
Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos, Curr. Biol. CB, vol.12, pp.1670-1674, 2002. ,
Poleward Tubulin Flux in Spindles: Regulation and Function in Mitotic Cells, Mol. Biol. Cell, vol.18, pp.3094-3104, 2007. ,
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2, J. Cell Biol, vol.154, pp.925-936, 2001. ,
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores, J. Cell Biol, vol.161, pp.267-280, 2003. ,
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis, Nat. Commun, vol.2, p.316, 2011. ,
Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest, Sci. Rep, vol.7, p.16762, 2017. ,
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer, PLoS Biol, vol.6, p.50, 2008. ,
Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation, J. Cell Biol, vol.155, pp.1159-1172, 2001. ,
KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint, Curr. Biol. CB, vol.21, pp.942-947, 2011. ,
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing, Curr. Biol. CB, vol.14, pp.942-952, 2004. ,
p31comet blocks Mad2 activation through structural mimicry, Cell, vol.131, pp.744-755, 2007. ,
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint, EMBO J, vol.23, pp.3133-3143, 2004. ,
Single cell sequencing reveals low levels of aneuploidy across mammalian tissues, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.13409-13414, 2014. ,
Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System, Dev. Cell, vol.41, p.5, 2017. ,
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism, J. Cell Biol, vol.188, pp.369-381, 2010. ,
Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation, Nat. Cell Biol, vol.18, pp.668-675, 2016. ,
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells, Mol. Syst. Biol, vol.8, p.608, 2012. ,
Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos, Cancer Metastasis Rev, vol.32, pp.377-389, 2013. ,
Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation, FEBS Lett, vol.585, pp.1121-1126, 2011. ,
Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution, Cell. Microbiol, vol.9, pp.1601-1610, 2007. ,
, Exons -Homo sapiens -Ensembl genome browser 97, vol.13, p.22, 2019.
Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains, Angew. Chem. Int. Ed, vol.58, pp.2627-2631, 2019. ,
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution, EMBO J, vol.16, pp.3787-3796, 1997. ,
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses, Neurochem. Int, vol.56, pp.911-918, 2010. ,
Control of cullin-ring ubiquitin ligase activity by nedd8, Subcell. Biochem, vol.54, pp.41-56, 2010. ,
Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases, Biochemistry, vol.37, pp.3358-3368, 1998. ,
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate, J. Biol. Chem, vol.280, pp.1512-1520, 2005. ,
Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases: Identification of Two Active Site Residues, Biochemistry, vol.35, pp.6735-6744, 1996. ,
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations, J. Biol. Chem, vol.284, pp.3593-3602, 2009. ,
The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3, J. Mol. Biol, vol.291, pp.1067-1077, 1999. ,
An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina, Hum. Mol. Genet, vol.12, pp.1301-1312, 2003. ,
Ubiquitin Cterminal hydrolase L3 (Uchl3) is involved in working memory, Hippocampus, vol.15, pp.610-621, 2005. ,
Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis, Endocrinology, vol.150, pp.5230-5239, 2009. ,
Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.23, pp.4148-4157, 2009. ,
The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage, Sci. Rep, vol.8, p.17891, 2018. ,
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer, Cancer Sci, vol.97, pp.523-529, 2006. ,
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines, Mol. Carcinog, vol.45, pp.260-269, 2006. ,
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines, Biochem. Biophys. Res. Commun, vol.452, pp.722-727, 2014. ,
The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel, J. Biol. Chem, vol.282, pp.37885-37893, 2007. ,
Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation, J. Cell. Physiol, vol.227, pp.2022-2029, 2012. ,
Discovering centromere proteins: from cold white hands to the A, B, C of CENPs, Nat. Rev. Mol. Cell Biol, vol.16, pp.443-449, 2015. ,
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors, Nat. Genet, vol.37, pp.1289-1295, 2005. ,
No chromosome left behind: The importance of metaphase alignment for mitotic fidelity, J. Cell Biol, vol.218, pp.1086-1088, 2019. ,
Mitotic chromosome alignment is required for proper nuclear envelope reassembly, Cell Biology, 2018. ,
Phosphorylation of Astrin Regulates Its Kinetochore Function, J. Biol. Chem, vol.291, pp.17579-17592, 2016. ,
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation, J. Clin. Invest, vol.122, pp.4325-4328, 2012. ,
Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases, Signal Transduct. Target. Ther, vol.3, 2018. ,
ATM controls proper mitotic spindle structure, Cell Cycle Georget. Tex, vol.13, pp.1091-1100, 2014. ,
Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice, Mutat. Res, vol.477, pp.183-189, 2001. ,
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis, J. Cell Sci, vol.115, pp.71-79, 2002. ,
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis, Oncotarget, vol.8, pp.48671-48687, 2017. ,
, , p.16, 2019.
Expression and Functional Analysis of Uch-L3 during Mouse Development, Mol. Cell. Biol, vol.20, pp.2498-2504, 2000. ,
Chromosomes Can Congress to the Metaphase Plate Before Biorientation, Science, vol.311, pp.388-391, 2006. ,
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces, Nat. Cell Biol, vol.16, pp.1249-1256, 2014. ,
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips, Nat. Cell Biol, vol.15, pp.1079-1088, 2013. ,
CENP-meta, an Essential Kinetochore Kinesin Required for the Maintenance of Metaphase Chromosome Alignment in Drosophila, J. Cell Biol, vol.150, pp.1-12, 2000. ,
Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression, J. Cell Sci, vol.117, pp.1577-1589, 2004. ,
CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint, Nat. Cell Biol, vol.2, p.484, 2000. ,
The mitotic-spindleassociated protein astrin is essential for progression through mitosis, J. Cell Sci, vol.115, pp.4053-4059, 2002. ,
Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80, 2017. ,
Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores, J. Cell Biol, vol.191, pp.269-280, 2010. ,
The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment, J. Cell Biol, vol.192, pp.959-968, 2011. ,
PRC1-labeled microtubule bundles and kinetochore pairs show one-to-one association in metaphase, EMBO Rep, vol.18, pp.217-230, 2017. ,
Spindle Size Scaling Contributes to Robust Silencing of Mitotic Spindle Assembly Checkpoint, Biophys. J, vol.111, pp.1064-1077, 2016. ,
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A, J. Cell Biol, vol.202, pp.605-621, 2013. ,
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A, J. Cell Biol, vol.182, pp.289-300, 2008. ,
Length-dependent anisotropic scaling of spindle shape, Biol. Open, vol.3, pp.1217-1223, 2014. ,
Lateral to end-on conversion of chromosomemicrotubule attachment requires kinesins CENP-E and MCAK, Curr. Biol. CB, vol.23, pp.1514-1526, 2013. ,
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells, Nat. Commun, vol.8, 2017. ,
Anaphase spindle mechanics prevent missegregation of merotelically oriented chromosomes, Curr. Biol. CB, vol.14, pp.2149-2155, 2004. ,
Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells, J. Cell Sci, vol.115, pp.507-515, 2002. ,
Depletion of p31comet protein promotes sensitivity to antimitotic drugs, J. Biol. Chem, vol.287, pp.21561-21569, 2012. ,
Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein, J. Biol. Chem, vol.289, pp.23928-23937, 2014. ,
Modeling dual pathways for the metazoan spindle assembly checkpoint, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.16758-16763, 2006. ,
Protein Metamorphosis: The Two-State Behavior of Mad2, Struct. Lond. Engl, vol.16, p.1616, 1993. ,
The role of localization in the operation of the mitotic spindle assembly checkpoint, Cell Cycle, vol.8, pp.2650-2660, 2009. ,
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle, J. Cell Biol, vol.127, pp.1301-1310, 1994. ,
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores, J. Cell Biol, vol.130, pp.941-948, 1995. ,
Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage, Proc. Natl. Acad. Sci. U. S. A, vol.94, pp.5107-5112, 1997. ,
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore, J. Cell Biol, vol.177, pp.1005-1015, 2007. ,
p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit, J. Cell Sci, vol.124, pp.3905-3916, 2011. ,
p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs, SpringerPlus, vol.2, p.562, 2013. ,
Aurora B is enriched at merotelic attachment sites, where it regulates MCAK, Curr. Biol. CB, vol.16, pp.1705-1710, 2006. ,
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine, J. Cell Biol, vol.190, pp.73-87, 2010. ,
Does aneuploidy cause cancer?, Curr. Opin. Cell Biol, vol.18, pp.658-667, 2006. ,
Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications, Cancer Metastasis Rev, vol.36, pp.669-682, 2017. ,
, Expression of UCHL3 in cancer -Summary -The Human Protein Atlas, p.17, 2019.
A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair, Cell Death Dis, vol.10, 2019. ,
TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases, BioEssays, vol.27, pp.1147-1157, 2005. ,
Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity, EMBO J, vol.35, pp.1204-1218, 2016. ,
In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML, Proc. Natl. Acad. Sci, vol.93, pp.1601-1606, 1996. ,
The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors, Immunity, vol.38, pp.384-398, 2013. ,
Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2, Cancer Res, vol.68, pp.5572-5580, 2008. ,
TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth, Biochem. Biophys. Res. Commun, vol.388, pp.422-427, 2009. ,
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin, Nat. Commun, vol.6, p.7299, 2015. ,
TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells, J. Cell Sci, vol.125, pp.1544-1555, 2012. ,
PML protein isoforms and the RBCC/TRIM motif, Oncogene, vol.20, pp.7223-7233, 2001. ,
TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle, PLoS Pathog, vol.4, p.16, 2008. ,
The cytoplasmic body component TRIM5? restricts HIV-1 infection in Old World monkeys, Nature, vol.427, pp.848-853, 2004. ,
Human Molecular Genetic and Functional Studies Identify TRIM63 , Encoding Muscle RING Finger Protein 1, as a Novel Gene for Human Hypertrophic Cardiomyopathy, Circ. Res, vol.111, pp.907-919, 2012. ,
The M694V Variant of the Familial Mediterranean Fever Gene Is Associated with Sporadic Early-Onset Alzheimer's Disease in an Italian Population Sample, Dement. Geriatr. Cogn. Disord, vol.23, pp.55-59, 2007. ,
MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation, Nat. Genet, vol.29, pp.287-294, 2001. ,
TRIM24 links a non-canonical histone signature to breast cancer, Nature, vol.468, pp.927-932, 2010. ,
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma, Proc. Natl. Acad. Sci, vol.108, pp.8212-8217, 2011. ,
Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties, BMC Evol. Biol, vol.8, p.225, 2008. ,
Genomics and Evolution of the TRIM Gene Family, TRIM/RBCC Proteins, vol.770, pp.1-9, 2012. ,
Subclassification of the RBCC/TRIM Superfamily Reveals a Novel Motif Necessary for Microtubule Binding, J. Biol. Chem, vol.281, pp.8970-8980, 2006. ,
Solution Structure of the RBCC/TRIM B-box1 Domain of Human MID1: B-box with a RING, J. Mol. Biol, vol.358, pp.532-545, 2006. ,
TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation, IUBMB Life, vol.64, pp.64-71, 2012. ,
TRIM family proteins and their emerging roles in innate immunity, Nat. Rev. Immunol, vol.8, pp.849-860, 2008. ,
Structural and functional insights into the B30.2/SPRY domain, EMBO J, vol.25, pp.1353-1363, 2006. ,
Determinants of the Higher Order Association of the Restriction Factor TRIM5? and Other Tripartite Motif (TRIM) Proteins, J. Biol. Chem, vol.286, pp.27959-27970, 2011. ,
The tripartite motif family identifies cell compartments, EMBO J, vol.20, pp.2140-2151, 2001. ,
Functional interactions between ubiquitin E2 enzymes and TRIM proteins, Biochem. J, vol.434, pp.309-319, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00565906
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21, Nat. Immunol, vol.14, pp.327-336, 2013. ,
The Role of Tripartite Motif Family Proteins in TGF-? Signaling Pathway and Cancer, J. Cancer Prev, vol.23, pp.162-169, 2018. ,
Mechanisms, regulation and consequences of protein SUMOylation, Biochem. J, vol.428, pp.133-145, 2010. ,
The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions, Mol. Cell. Biol, vol.30, pp.3004-3015, 2010. ,
, E3 Ubiquitin Ligase TRIM Proteins, vol.8, p.510, 2019.
Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology, Oncogene, 2019. ,
TRIM8 modulates p53 activity to dictate cell cycle arrest, Cell Cycle, vol.11, pp.511-523, 2012. ,
TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway, Sci. Rep, vol.7, p.42411, 2017. ,
TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/?-catenin pathway, Oncol. Rep, 2019. ,
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-Imediated antiviral activity, Nature, vol.446, pp.916-920, 2007. ,
Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I, Cell Host Microbe, vol.5, pp.439-449, 2009. ,
HIV-1 capsid recognition, and innate immune signaling, Curr. Opin. Virol, vol.2, pp.142-150, 2012. ,
Molecular Cloning of a New Interferon-induced Factor That Represses Human Immunodeficiency Virus Type 1 Long Terminal Repeat Expression, J. Biol. Chem, vol.270, pp.14891-14898, 1995. ,
URL : https://hal.archives-ouvertes.fr/hal-02361053
The TRIM Family Protein KAP1 Inhibits HIV-1 Integration, Cell Host Microbe, vol.9, pp.484-495, 2011. ,
TRIM proteins and diseases, J. Biochem. (Tokyo), p.87, 2017. ,
Limb-girdle muscular dystrophy 2H and the role of TRIM32, Handbook of Clinical Neurology, vol.101, pp.125-133, 2011. ,
TRIM11 Upregulation Contributes to Proliferation, Invasion, and EMT of Hepatocellular Carcinoma Cells, Oncol. Res. Featur. Preclin. Clin. Cancer Ther, vol.25, pp.691-699, 2017. ,
The complexity of TRIM28 contribution to cancer, J. Biomed. Sci, vol.24, p.63, 2017. ,
TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma, Oncotarget, vol.5, 2014. ,
The Epithelial-to-Mesenchymal Transition in Cancer, Cancers, vol.10, p.52, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01660995
Tripartite motif-containing 14 (TRIM14) promotes epithelialmesenchymal transition via ZEB2 in glioblastoma cells, J. Exp. Clin. Cancer Res, vol.38, p.57, 2019. ,
The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox, Cell Adhes. Migr, vol.3, pp.334-336, 2009. ,
TRIM25 blockade by RNA interference inhibited migration and invasion of gastric cancer cells through TGF-? signaling, Sci. Rep, vol.6, p.19070, 2016. ,
TRIM14 promotes colorectal cancer cell migration and invasion through the SPHK1/STAT3 pathway, Cancer Cell Int, vol.18, p.202, 2018. ,
The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer, Oncotarget, vol.7, 2016. ,
TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1-TSC2 complex, Oncogene, vol.37, pp.478-488, 2018. ,
TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination, Cell Death Dis, vol.8, pp.2831-2831, 2017. ,
Analysis of Genome-Wide Association Study (GWAS) data looking for replicating signals in Alzheimer's disease (AD), Int. J. Mol. Epidemiol. Genet, vol.1, pp.53-66, 2010. ,
TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity, J. Virol, vol.87, pp.257-272, 2013. ,
TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly, J. Cell Sci, vol.127, pp.3928-3942, 2014. ,
TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma, Med. Sci. Monit, vol.24, pp.8033-8041, 2018. ,
Role of the focal adhesion protein TRIM15 in colon cancer development, Biochim. Biophys. Acta BBA -Mol. Cell Res, vol.1853, pp.409-421, 2015. ,
TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction, Nucleic Acids Res, vol.40, pp.117-122, 2012. ,
, ATCC Cell Lines. Available at, p.16, 2019.
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene, Science, vol.278, pp.120-123, 1997. ,
The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies, J. Carcinog, vol.10, p.9, 2011. ,
TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly, J. Cell Sci, vol.127, pp.3928-3942, 2014. ,
TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly, J. Cell Sci, vol.127, pp.3928-3942, 2014. ,
Role of the focal adhesion protein TRIM15 in colon cancer development, Biochim. Biophys. Acta BBA -Mol. Cell Res, vol.1853, pp.409-421, 2015. ,
Selection of reference genes for quantitative RT-PCR (RT-qPCR) analysis of rat tissues under physiological and toxicological conditions, PeerJ, vol.3, p.855, 2015. ,
Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium, Sci. Rep, vol.9, p.1629, 2019. ,
TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma, Med. Sci. Monit, vol.24, pp.8033-8041, 2018. ,
Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough, Biochim. Biophys. Acta, vol.1552, pp.39-45, 2001. ,
The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox, Cell Adhes. Migr, vol.3, pp.334-336, 2009. ,
in a Mouse Mammary Epithelial Cell Line NMuMG by Using cDNA Microarray DEK and Proto-oncogene Cyclin B 1-regulated Genes that Include ING 1 Identification of the p 33 Updated, 2002. ,
, OS ATCC ® HTB-96 TM Homo sapiens bone osteosarcoma, p.23, 2019.