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Journal Articles Nature Medicine Year : 2019

The molecular landscape of glioma in patients with Neurofibromatosis 1

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Fulvio d'Angelo
  • Function : Author
Michele Ceccarelli
Jing Zhang
Véronique Frattini
  • Function : Author
Francesca Caruso
  • Function : Author
Kristin Alfaro
  • Function : Author
Giulia Berzero
  • Function : Author
Mario Cangiano
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Stéphane Goutagny
Cinzia Lavarino
  • Function : Author
Hugues Loiseau
  • Function : Author
Véronique Lorgis
  • Function : Author
Carlo Marras
  • Function : Author
Ian Mccutcheon
Do-Hyun Nam
  • Function : Author
Susanna Ronchi
  • Function : Author
Veronica Saletti
  • Function : Author
Romuald Seizeur
  • Function : Author
John Slopis
  • Function : Author
Mariona Suñol
  • Function : Author
Fanny Vandenbos
  • Function : Author
Pascale Varlet
  • Function : Author
Dominique Vidaud
  • Function : Author
Colin Watts
  • Function : Author
Viviane Tabar
  • Function : Author
David Reuss
  • Function : Author
Seung-Ki Kim
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David Meyronet
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Karima Mokhtari
  • Function : Author
Hector Salvador
Krishna Bhat
  • Function : Author
Marica Eoli
  • Function : Author
Marc Sanson
  • Function : Author
Anna Lasorella
Antonio Iavarone
Fulvio D’angelo

Abstract

Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma). We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade. High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways. Low-grade tumors exhibited fewer mutations that were over-represented in genes of the MAP kinase pathway. Approximately 50% of low-grade NF1-gliomas displayed an immune signature, T lymphocyte infiltrates, and increased neo-antigen load. DNA methylation assigned NF1-glioma to LGm6, a poorly defined Isocitrate Dehydrogenase 1 wild-type subgroup enriched with ATRX mutations. Thus, the profiling of NF1-glioma defined a distinct landscape that recapitulates a subset of sporadic tumors.

Dates and versions

hal-03905472 , version 1 (18-12-2022)

Identifiers

Cite

Fulvio d'Angelo, Michele Ceccarelli, Luciano Garofano, Jing Zhang, Véronique Frattini, et al.. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nature Medicine, 2019, 25 (1), pp.176-187. ⟨10.1038/s41591-018-0263-8⟩. ⟨hal-03905472⟩
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