Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma - Archive ouverte HAL Access content directly
Journal Articles Neuropathology and Applied Neurobiology Year : 2022

Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

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Christian Mirian
Kathrine Grell
Tareq A Juratli
Sabine Spiegl‐kreinecker
  • Function : Author
Matthieu Peyre
  • Function : Author
Annamaria Biczok
  • Function : Author
Jörg‐christian Tonn
  • Function : Author
Luca Bertero
Lasse Rehné Jensen
Gabriele Schackert
  • Function : Author
Helle Broholm
  • Function : Author
Daniel P Cahill
  • Function : Author
Jane Skjøth‐rasmussen
  • Function : Author
Kåre Fugleholm
  • Function : Author
Morten Ziebell
  • Function : Author
Tina Nørgaard Munch
Bjarne Winther Kristensen
  • Function : Author

Abstract

TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.
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Dates and versions

hal-03905440 , version 1 (18-12-2022)

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Cite

Christian Mirian, Kathrine Grell, Tareq A Juratli, Felix Sahm, Sabine Spiegl‐kreinecker, et al.. Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma. Neuropathology and Applied Neurobiology, 2022, 48 (3), pp.e12773. ⟨10.1111/nan.12773⟩. ⟨hal-03905440⟩

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