In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response - Archive ouverte HAL Access content directly
Journal Articles Science Immunology Year : 2021

In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response

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Aurélien Sutra del Galy
Laetitia Perrin
  • Function : Author
Julie Helft
Aurélie Darbois
  • Function : Author
Michael Saitakis
Jimena Tosello
Derek Rookhuizen
  • Function : Author
Pierre Gestraud
Gérard Socié
Sebastian Amigorena
Olivier Lantz
Laurie Menger

Abstract

Inactivation of SOCS1 optimizes adoptive T cell therapy including human CAR-T cell composition and efficacy.
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Dates and versions

hal-03877499 , version 1 (29-11-2022)

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Cite

Aurélien Sutra del Galy, Silvia Menegatti, Jaime Fuentealba, Francesca Lucibello, Laetitia Perrin, et al.. In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response. Science Immunology, 2021, 6 (66), ⟨10.1126/sciimmunol.abe8219⟩. ⟨hal-03877499⟩
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