In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response

Aurélien Sutra del Galy (1) , Silvia Menegatti (2, 3) , Jaime Fuentealba (4) , Francesca Lucibello (3) , Laetitia Perrin , Julie Helft (3) , Aurélie Darbois , Michael Saitakis , Jimena Tosello , Derek Rookhuizen , Marc Deloger (5) , Pierre Gestraud (6) , Gérard Socié (1) , Sebastian Amigorena (6) , Olivier Lantz (3) , Laurie Menger

1 AP-HP - Hopital Saint-Louis [AP-HP]
2 USPC - Université Sorbonne Paris Cité
3 U932 - Immunité et cancer
4 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
5 Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe
6 Institut Curie [Paris]

Inactivation of SOCS1 optimizes adoptive T cell therapy including human CAR-T cell composition and efficacy.

Domains: Life Sciences [q-bio]

Aurélien Sutra del Galy, Silvia Menegatti, Jaime Fuentealba, Francesca Lucibello, Laetitia Perrin, et al.. In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response. Science Immunology, 2021, 6 (66), ⟨10.1126/sciimmunol.abe8219⟩. ⟨hal-03877499⟩