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Biological effects of the loss of homochirality in a multicellular organism

Abstract : Abstract Homochirality is a fundamental feature of all known forms of life, maintaining biomolecules (amino-acids, proteins, sugars, nucleic acids) in one specific chiral form. While this condition is central to biology, the mechanisms by which the adverse accumulation of non- l- α-amino-acids in proteins lead to pathophysiological consequences remain poorly understood. To address how heterochirality build-up impacts organism’s health, we use chiral-selective in vivo assays to detect protein-bound non -l -α-amino acids (focusing on aspartate) and assess their functional significance in Drosophila . We find that altering the in vivo chiral balance creates a ‘heterochirality syndrome’ with impaired caspase activity, increased tumour formation, and premature death. Our work shows that preservation of homochirality is a key component of protein function that is essential to maintain homeostasis across the cell, tissue and organ level.
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Contributor : Stéphane NOSELLI Connect in order to contact the contributor
Submitted on : Monday, November 21, 2022 - 11:00:06 AM
Last modification on : Saturday, November 26, 2022 - 9:04:04 AM

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Agnes Banreti, Shayon Bhattacharya, Frank Wien, Koichi Matsuo, Matthieu Réfrégiers, et al.. Biological effects of the loss of homochirality in a multicellular organism. Nature Communications, 2022, 13 (1), pp.7059. ⟨10.1038/s41467-022-34516-x⟩. ⟨hal-03862765⟩



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