Urinary metabolites give new clues to kidney transplant tolerance

Nuala Mooney (1)

1 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie

Kidney transplantation is the treatment of choice for patients with end-stage kidney disease. While the procedure is very successful in the first years following transplantation, long-term rejection of allografts remains a major problem despite immunosuppression and a further difficulty is the worldwide shortage of organs suitable for transplant. There is therefore a tremendous need to identify new therapeutic pathways that could be targeted to improve the long-term survival of kidney transplants. The study published in this issue of eBio-Medicine by Colas et al. takes a novel approach to understanding operational tolerance by performing urinary metabolomic profiling, using ultrahigh performance liquid chromatography with high resolution mass spectrometry. The results identify a urinary metabolomic signature in a cohort of spontaneously tolerant kidney transplant recipients. 1 This unique cohort is defined by the stable and acceptable function of their allografts in the absence of immunosuppressive treatments. 2 To date the mechanisms underlying such tolerance have not been fully elucidated despite data indicating distinct immunological modifications in the operationally tolerant group (eg in regulatory B and T follicular helper lymphocytes 3,4

Domaines: Sciences du Vivant [q-bio]

Nuala Mooney. Urinary metabolites give new clues to kidney transplant tolerance. EBioMedicine, 2022, 77, pp.103935. ⟨10.1016/j.ebiom.2022.103935⟩. ⟨hal-03857820⟩