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Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR-mutant NSCLC

Abstract : Drug-tolerant "dormant" cells (DTC) have emerged as one of the major non-genetic mechanisms driving resistance to targeted therapy in lung cancer, although the sequence of events leading to entry and exit from dormancy remain poorly described. Here, we performed real-time monitoring of the cell cycle dynamics during the adaptive response to Epidermal Growth Factor Receptor tyrosine kinase inhibitors (EGFR-TKi) in a panel of EGFR-mutated lung cancer cell lines. We identified a rare population of S/G2 cycling cells (referred to as early escapers) that emerged in the first
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Preprints, Working Papers, ...
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https://hal-cnrs.archives-ouvertes.fr/hal-03843955
Contributor : Olivier Calvayrac Connect in order to contact the contributor
Submitted on : Tuesday, November 8, 2022 - 2:24:59 PM
Last modification on : Wednesday, November 23, 2022 - 12:02:20 PM

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2022.04.01.486707v1.full.pdf
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Sarah Figarol, Célia Delahaye, Rémi Gence, Raghda Asslan, Sandra Pagano, et al.. Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR-mutant NSCLC. 2022. ⟨hal-03843955⟩

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