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Conference poster

Autistic-like behavioral effects of prenatal stress in the FMR1-KO mouse model of fragile X syndrome

Abstract : Fragile X Syndrome (FXS) is the most common heritable form of mental retardation and the main monogenic cause of autism spectrum disorder (ASD). FXS is due to a mutation in the X-linked FMR1 human gene consisting in more than 200 CGG repetitions leading to the absence of FMRP protein and is characterized by motor, cognitive and social alterations, mostly overlapping with autism spectrum disorder behavioral phenotypes. FXS behavioral phenotype can be critically modulated by environmental factors e.g., stress exposure, both in terms of its severity and of the timing of appearance.
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https://hal-cnrs.archives-ouvertes.fr/hal-03834348
Contributor : susanna pietropaolo Connect in order to contact the contributor
Submitted on : Saturday, October 29, 2022 - 3:31:28 PM
Last modification on : Friday, November 25, 2022 - 6:32:08 PM

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Distributed under a Creative Commons Attribution 4.0 International License

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  • HAL Id : hal-03834348, version 1

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Valeria Petroni, Enejda Subashi, Marika Premoli, Markus Wöhr, Wim E. Crusio, et al.. Autistic-like behavioral effects of prenatal stress in the FMR1-KO mouse model of fragile X syndrome. FENS Annual Meeting 2022, Jul 2022, Paris, France. . ⟨hal-03834348⟩

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