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Catch up saccades in vestibular hypofunction: a contribution of the cerebellum?

Abstract : Introduction: Long-term de cits of the vestibulo-ocular re ex (VOR) elicited by head rotation can be partially compensated by Catch-up Saccades (CuS). These saccades are initially visually guided but their latency can greatly decrease resulting in Short Latency CuS. It is still unclear what triggers these CuS and what are the underlying neural circuits. In this study, we aimed at evaluating the impact of cerebellar pathology on CuS by comparing their latency between two groups of patients with bilateral vestibular hypofunction, with or without additional cerebellar dysfunction. Method: We recruited 12 patients with both bilateral vestibular hypofunction and cerebellar dysfunction (BVH-CD group) and 12 patients with isolated bilateral vestibular hypofunction (BVH group). Both groups were matched for age and residual VOR gain. Subjects underwent video head impulse test recording of the horizontal semi-circular canals responses as well as recording of visually guided saccades in the Step, Gap and Overlap paradigms. Latency and gain of the different saccades were calculated. Results: Mean age for BVH-CD and BVH was respectively 67.8 and 67.2 years and mean residual VOR gain was respectively 0.24 and 0.26. Mean latency of the rst catch-up saccade was signi cantly longer for the BVH-CD group than for the BVH group (204ms vs 145ms, p<0.05). There was no signi cant difference in the latency of visually guided saccades between the two groups, for none of the three paradigms. Conclusion: Our results suggest that the cerebellum plays a role in the generation of compensatory SL-CuS observed in BVH patients.
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Preprints, Working Papers, ...
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Contributor : Denis Pelisson Connect in order to contact the contributor
Submitted on : Thursday, October 27, 2022 - 2:31:11 PM
Last modification on : Friday, November 4, 2022 - 10:34:52 AM


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Ruben Hermann, Camille Robert, Vincent Lagadec, Mathieu Dupre, Denis Pélisson, et al.. Catch up saccades in vestibular hypofunction: a contribution of the cerebellum?. 2022. ⟨hal-03832172⟩



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