Skip to Main content Skip to Navigation
New interface
Journal articles

Synthesis of indoles through acceptorless dehydrogenative coupling catalyzed by nickel on silica-alumina

Abstract : The high atom-economical formation of indoles from anilines and diols was described with affordable and easy to handle Ni/SiO2-Al2O3. After optimization, 2,3-dimethylindole was isolated with an excellent 98% yield in neat conditions. The scope of the reaction was studied and 13 indoles were isolated in 16-80% yields.
Document type :
Journal articles
Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03821327
Contributor : Nicolas Duguet Connect in order to contact the contributor
Submitted on : Thursday, October 20, 2022 - 6:09:47 PM
Last modification on : Friday, October 21, 2022 - 4:06:33 AM

File

TL Aubin_HAL.pdf
Files produced by the author(s)

Identifiers

Citation

Aubin Charvieux, Abdul Aziz Hammoud, Marie-Christine Duclos, Nicolas Duguet, Estelle Métay. Synthesis of indoles through acceptorless dehydrogenative coupling catalyzed by nickel on silica-alumina. Tetrahedron Letters, 2021, 78, pp.153270. ⟨10.1016/j.tetlet.2021.153270⟩. ⟨hal-03821327⟩

Share

Metrics

Record views

0

Files downloads

0