Skip to Main content Skip to Navigation
New interface
Preprints, Working Papers, ...

Telomere elongation in the gut extends zebrafish lifespan

Abstract : Telomere shortening is a hallmark of aging and is counteracted by telomerase. The gut is one of the earliest organs to exhibit short telomeres and tissue dysfunction during normal zebrafish aging. This is recapitulated in prematurely aged telomerase mutants ( tert-/- ). Here, we show that gut-specific telomerase activity in tert-/- zebrafish prevents premature aging. Induction of telomerase rescues gut senescence and low cell proliferation to wild-type levels, while restoring gut tissue integrity, inflammation, and age-dependent gut microbiota dysbiosis. Remarkably, averting gut dysfunction results in a systemic beneficial impact. Gut-specific telomerase activity rescues premature aging markers in remote organs, such as the reproductive (testes) and hematopoietic (kidney marrow) systems. Functionally, it also rescues age-dependent loss of male fertility and testes atrophy. Finally, we show that gut-specific telomerase activity increases the lifespan of telomerase mutants. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.
Document type :
Preprints, Working Papers, ...
Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03817707
Contributor : Miguel GODINHO FERREIRA Connect in order to contact the contributor
Submitted on : Monday, October 17, 2022 - 2:10:42 PM
Last modification on : Tuesday, October 18, 2022 - 4:12:53 AM

Identifiers

Collections

Citation

Mounir El Maï, Jean-Marie Guigonis, Thierry Pourchet, Da Kang, Jia-Xing Yue, et al.. Telomere elongation in the gut extends zebrafish lifespan. 2022. ⟨hal-03817707⟩

Share

Metrics

Record views

0