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The Hazards of Regeneration: From Morgan’s Legacy to Evo-Devo

Abstract : Abstract In his prominent book Regeneration (1901), T.H. Morgan’s collected and synthesized theoretical and experimental findings from a diverse array of regenerating animals and plants. Through his endeavor, he introduced a new way to study regeneration and its evolution, setting a conceptual framework that still guides today’s research and that embraces the contemporary evolutionary and developmental approaches. In the first part of the chapter, we summarize Morgan’s major tenets and use it as a narrative thread to advocate interpreting regenerative biology through the theoretical tools provided by evolution and developmental biology, but also to highlight potential caveats resulting from the rapid proliferation of comparative studies and from the expansion of experimental laboratory models. In the second part, we review some experimental evo-devo approaches, highlighting their power and some of their interpretative dangers. Finally, in order to further understand the evolution of regenerative abilities, we portray an adaptive perspective on the evolution of regeneration and suggest a framework for investigating the adaptive nature of regeneration.
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https://hal-cnrs.archives-ouvertes.fr/hal-03815577
Contributor : Stefano Tiozzo Connect in order to contact the contributor
Submitted on : Thursday, November 24, 2022 - 1:12:49 PM
Last modification on : Friday, November 25, 2022 - 11:16:35 AM

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Chiara Sinigaglia, Alexandre Alié, Stefano Tiozzo. The Hazards of Regeneration: From Morgan’s Legacy to Evo-Devo. Whole-Body Regeneration, 2450, Springer US, pp.3-25, 2022, Methods in Molecular Biology, ⟨10.1007/978-1-0716-2172-1_1⟩. ⟨hal-03815577⟩

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