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Nucleation, stabilization, and disassembly of branched actin networks

Abstract : Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing forces that drive cellular processes ranging from membrane remodeling to cell and organelle motility. Several molecules regulate these processes by directly inhibiting or activating Arp2/3 complex and by stabilizing or disassembling branched networks. Here, we review recent advances in our understanding of Arp2/3 complex regulation, including high-resolution cryoelectron microscopy (cryo-EM) structures that illuminate the mechanisms of Arp2/3 complex activation and branch formation, and novel cellular pathways of branch formation, stabilization, and debranching. We also identify major gaps in our understanding of Arp2/3 complex inhibition and branch stabilization and disassembly.
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Contributor : Alexis Gautreau Connect in order to contact the contributor
Submitted on : Friday, October 7, 2022 - 7:53:53 AM
Last modification on : Saturday, October 8, 2022 - 3:51:11 AM

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Alexis Gautreau, Fred Fregoso, Gleb Simanov, Roberto Dominguez. Nucleation, stabilization, and disassembly of branched actin networks. Trends in Cell Biology, 2022, 32 (5), pp.421-432. ⟨10.1016/j.tcb.2021.10.006⟩. ⟨hal-03804978⟩



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