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Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly

Abstract : Dynamic covalent polymers (DCPs) offer opportunities as adaptive materials of particular interest for targeting, sensing and delivery of biological molecules. In this view, combining cationic units and fluorescent units along DCP chains is attractive for achieving optical probes for the recognition and delivery of nucleic acids. Here, we report on the design of acylhydrazone-based DCPs combining cationic arginine units with π-conjugated fluorescent moieties based on thiopheneethynyl-fluorene cores. Two types of fluorescent building blocks bearing neutral or cationic side groups on the fluorene moiety are considered in order to assess the role of the number of cationic units on complexation with DNA. The (chir)optical properties of the building blocks, the DCPs, and their complexes with several types of DNA are explored, providing details on the formation of supramolecular complexes and on their stability in aqueous solutions. The DNA-templated formation of DCPs is demonstrated, which provides new perspectives on the assembly of fluorescent DCP based on the nucleic acid structure.
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https://hal-cnrs.archives-ouvertes.fr/hal-03800905
Contributor : Sebastien ULRICH Connect in order to contact the contributor
Submitted on : Thursday, October 6, 2022 - 4:27:10 PM
Last modification on : Wednesday, October 12, 2022 - 3:58:59 AM

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Clément Kotras, Maxime Leclercq, Maxime Roger, Camille Bouillon, Antonio Recupido, et al.. Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly. Molecules, 2022, ⟨10.3390/molecules27196648⟩. ⟨hal-03800905⟩

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