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Crustacean leg regeneration restores complex microanatomy and cell diversity

Abstract : Animals can regenerate complex organs, yet this process frequently results in imprecise replicas of the original structure. In the crustacean Parhyale , embryonic and regenerating legs differ in gene expression dynamics but produce apparently similar mature structures. We examine the fidelity of Parhyale leg regeneration using complementary approaches to investigate microanatomy, sensory function, cellular composition, and cell molecular profiles. We find that regeneration precisely replicates the complex microanatomy and spatial distribution of external sensory organs and restores their sensory function. Single-nuclei sequencing shows that regenerated and uninjured legs are indistinguishable in terms of cell-type composition and transcriptional profiles. This remarkable fidelity highlights the ability of organisms to achieve identical outcomes via distinct processes.
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https://hal-cnrs.archives-ouvertes.fr/hal-03799483
Contributor : Michalis Averof Connect in order to contact the contributor
Submitted on : Wednesday, October 5, 2022 - 10:29:12 PM
Last modification on : Thursday, October 13, 2022 - 8:55:35 AM

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Alba Almazán, Çağrı Çevrim, Jacob M Musser, M. Averof, Mathilde Paris. Crustacean leg regeneration restores complex microanatomy and cell diversity. Science Advances , 2022, 8 (34), pp.eabn9823. ⟨10.1126/sciadv.abn9823⟩. ⟨hal-03799483⟩

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