Skip to Main content Skip to Navigation
New interface
Book sections

Polymer modeling of 3D epigenome folding: application to Drosophila

Abstract : Mechanistic modeling in biology allows to investigate, based on first principles, if putative hypotheses are compatible with observations and to drive further experimental works. Along this line, polymer modeling has been instrumental in 3D genomics to better understand the impact of key mechanisms on the spatial genome organization. Here, I describe how polymer-based models can be practically used to study the role of epigenome in chromosome folding. I illustrate this methodology in the context of Drosophila epigenome folding.
Document type :
Book sections
Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03798004
Contributor : Daniel Jost Connect in order to contact the contributor
Submitted on : Wednesday, October 5, 2022 - 9:14:51 AM
Last modification on : Friday, October 7, 2022 - 3:07:42 PM

File

Jost_bookchapter_Jost_2021.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Daniel Jost. Polymer modeling of 3D epigenome folding: application to Drosophila. Hi-C Data Analysis, 2301, pp 293-305, 2021, Methods in Molecular Biology, ⟨10.1007/978-1-0716-1390-0_15⟩. ⟨hal-03798004⟩

Share

Metrics

Record views

6

Files downloads

1