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Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

Hongjie Li 1 Jasper Janssens Maxime de Waegeneer Sai Saroja Kolluru Kristofer Davie Vincent Gardeux Wouter Saelens Fabrice David Maria Brbić Katina Spanier Jure Leskovec Colleen Mclaughlin Qijing Xie Robert Jones Katja Brueckner Jiwon Shim Sudhir Gopal Tattikota Frank Schnorrer 2 Katja Rust Todd Nystul Zita Carvalho-Santos Carlos Ribeiro Soumitra Pal Sharvani Mahadevaraju Teresa Przytycka Aaron Allen Stephen Goodwin Cameron Berry Margaret Fuller Helen White-Cooper Erika Matunis Stephen Dinardo Anthony Galenza Lucy Erin O’brien Julian Dow Heinrich Jasper Brian Oliver Norbert Perrimon Bart Deplancke Stephen Quake Liqun Luo Stein Aerts Devika Agarwal Yasir Ahmed-Braimah Michelle Arbeitman Majd Ariss Jordan Augsburger Kumar Ayush Catherine Baker Torsten Banisch Katja Birker Rolf Bodmer Benjamin Bolival Susanna Brantley Julie Brill Nora Brown Norene Buehner Xiaoyu Tracy Cai Rita Cardoso-Figueiredo Fernando Casares Amy Chang Thomas Clandinin Sheela Crasta Claude Desplan Angela Detweiler Darshan Dhakan Erika Donà Stefanie Engert Swann Floc’hlay Nancy George Amanda González-Segarra Andrew Groves Samantha Gumbin Yanmeng Guo Devon Harris Yael Heifetz Stephen Holtz Felix Horns Bruno Hudry Ruei-Jiun Hung Yuh Nung Jan Jacob Jaszczak Gregory Jefferis Jim Karkanias Timothy Karr Nadja Sandra Katheder James Kezos Anna Kim Seung Kim Lutz Kockel Nikolaos Konstantinides Thomas Kornberg Henry Krause Andrew Thomas Labott Meghan Laturney Ruth Lehmann Sarah Leinwand Jiefu Li Joshua Shing Shun Li Kai Li Ke Li Liying Li Tun Li Maria Litovchenko Han-Hsuan Liu Yifang Liu Tzu-Chiao Lu Jonathan Manning Anjeli Mase Mikaela Matera-Vatnick Neuza Reis Matias Caitlin Mcdonough-Goldstein Aaron Mcgeever Alex Mclachlan Paola Moreno-Roman Norma Neff Megan Neville Sang Ngo Tanja Nielsen Caitlin O’brien David Osumi-Sutherland Mehmet Neset Özel Irene Papatheodorou Maja Petkovic Clare Pilgrim Angela Oliveira Pisco Carolina Reisenman Erin Nicole Sanders Gilberto dos Santos Kristin Scott Aparna Sherlekar Philip Shiu David Sims Rene Sit Maija Slaidina Harold Smith Gabriella Sterne Yu-Han Su Daniel Sutton Marco Tamayo Michelle Tan Ibrahim Tastekin Christoph Treiber David Vacek Georg Vogler Scott Waddell Wanpeng Wang Rachel Wilson Mariana Wolfner Yiu-Cheung Wong Anthony Xie Jun Xu Shinya Yamamoto Jia Yan Zepeng Yao Kazuki Yoda Ruijun Zhu Robert Zinzen 
Abstract : For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae , that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type–related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.
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https://hal-cnrs.archives-ouvertes.fr/hal-03795698
Contributor : Nikolaos Konstantinides Connect in order to contact the contributor
Submitted on : Monday, October 17, 2022 - 3:24:52 PM
Last modification on : Saturday, October 22, 2022 - 5:44:16 AM

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Hongjie Li, Jasper Janssens, Maxime de Waegeneer, Sai Saroja Kolluru, Kristofer Davie, et al.. Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science, 2022, 375 (6584), ⟨10.1126/science.abk2432⟩. ⟨hal-03795698⟩

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