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A NIR-II-emitting gold nanocluster-based drug delivery system for smartphonetriggered photodynamic theranostics with rapid body clearance

Abstract : Nanomedicine has grown structurally complex in order to perform multiple tasks at a time. However, their unsatisfied reliability, uniformity and reproducibility account for the high rates of attrition in translational research. So far, most studies have been one-sidedly focused on treatment efficacy of inorganic nanoparticles as cancer therapeutics, but overlook their elimination from the bodya key factor in getting regulatory approval. Instead of developing a new drug nanocarrier with uncertain future in medical practice, we therefore choose to leverage the utility of promising and translatable gold nanoclusters (AuNCs) for designing a simple but robust "all-in-one" nanocluster drug delivery system, where the AuNCs not only strengthen renal clearance of neutral red (NR) as a model drug, but also aid its passive tumor targeting via the enhanced permeability and retention (EPR) effect. More interestingly, NR can stimulate the production of reactive oxygen species (ROS) to suppress tumor growth under ultralow-level radiation with a smartphone's torch (fluence rate: 8.0 mW/cm 2). This finding is especially valuable to low-and middle-income countries lacking resources in healthcare settings. By means of first-principles simulations, we also study indepth the energies, structural and electronic properties of the AuNCs emitting in the second near-infrared window (1000 to 1700 nm). In brief, our model fulfills safety, effectiveness and cost-effectiveness requirements for translational development.
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https://hal-cnrs.archives-ouvertes.fr/hal-03740139
Contributor : xavier le guevel Connect in order to contact the contributor
Submitted on : Friday, July 29, 2022 - 7:58:25 AM
Last modification on : Thursday, August 4, 2022 - 3:24:03 AM

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Yifei Kong, David Santos-Carballal, David Martin, Natalia Sergeeva, Weili Wang, et al.. A NIR-II-emitting gold nanocluster-based drug delivery system for smartphonetriggered photodynamic theranostics with rapid body clearance. Materials Today, Elsevier, 2021, 51, pp.96-107. ⟨10.1016/j.mattod.2021.09.022⟩. ⟨hal-03740139⟩

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