Cell to network computational model of the epileptic human hippocampus suggests specific roles of network and channel dysfunctions in the ictal and interictal oscillations - Archive ouverte HAL Access content directly
Journal Articles Journal of Computational Neuroscience Year : 2022

Cell to network computational model of the epileptic human hippocampus suggests specific roles of network and channel dysfunctions in the ictal and interictal oscillations

(1, 2, 3) , (1) , (4) , (4) , (4) , (4) , (2)
1
2
3
4

Abstract

The mechanisms underlying the generation of hippocampal epileptic seizures and interictal events and their interactions with the sleep-wake cycle are not yet fully understood. Indeed, medial temporal lobe epilepsy is associated with hippocampal abnormalities both at the neuronal (channelopathies, impaired potassium and chloride dynamics) and network level (neuronal and axonal loss, mossy fiber sprouting), with more frequent seizures during wakefulness compared with slow-wave sleep. In this article, starting from our previous computational modeling work of the hippocampal formation based on realistic topology and synaptic connectivity, we study the role of microand mesoscale pathological conditions of the epileptic hippocampus in the generation and maintenance of seizure-like theta and interictal oscillations. We show, through the simulations of hippocampal activity during slow-wave sleep and wakefulness that: (i) both mossy fiber sprouting and sclerosis account for seizure-like theta activity, (ii) but they have antagonist effects (seizure-like activity occurrence increases with sprouting but decreases with sclerosis), (iii) though impaired potassium and chloride dynamics have little influence on the generation of seizure-like activity, they do play a role on the generation of interictal patterns, and (iv) seizure-like activity and fast ripples are more likely to occur during wakefulness and interictal spikes during sleep.
Fichier principal
Vignette du fichier
AusselRantaBuhry2022_JCN.pdf (2.37 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03721996 , version 1 (13-07-2022)

Identifiers

Cite

Amélie Aussel, Radu Ranta, Olivier Aron, Sophie Colnat-Coulbois, Louise Tyvaert, et al.. Cell to network computational model of the epileptic human hippocampus suggests specific roles of network and channel dysfunctions in the ictal and interictal oscillations. Journal of Computational Neuroscience, 2022, 50 (4), pp.519-535. ⟨10.1007/s10827-022-00829-5⟩. ⟨hal-03721996⟩
40 View
1135 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More