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Crystallography of polysaccharides: Current state and challenges

Abstract : Polysaccharides are the most abundant class of biopolymers, holding an important place in biological systems and sustainable material development. Their spatial organization and intra- and intermolecular interactions are thus of great interest. However, conventional single crystal crystallography is not applicable since polysaccharides crystallize only into tiny crystals. Several crystallographic methods have been developed to extract atomic-resolution structural information from polysaccharide crystals. Small-probe single crystal diffractometry, high-resolution fiber diffraction and powder diffraction combined with molecular modeling brought new insights from various types of polysaccharide crystals, and led to many highresolution crystal structures over the past two decades. Current challenges lie in the analysis of disorder and defects by further integrating molecular modeling methods for lowresolution diffraction data.
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https://hal-cnrs.archives-ouvertes.fr/hal-03714972
Contributor : Jean-Luc PUTAUX Connect in order to contact the contributor
Submitted on : Saturday, August 6, 2022 - 2:55:46 PM
Last modification on : Monday, August 8, 2022 - 12:49:43 PM

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Yu Ogawa, Jean-Luc Putaux, Yoshiharu Nishiyama. Crystallography of polysaccharides: Current state and challenges. Current Opinion in Chemical Biology, Elsevier, 2022, 70, pp.102183. ⟨10.1016/j.cbpa.2022.102183⟩. ⟨hal-03714972⟩

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