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Journal Articles Advanced Science Year : 2022

Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges

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Abstract

Actin is a fundamental member of an ancient superfamily of structural intracellular proteins and plays a crucial role in cytoskeleton dynamics, ciliogenesis, phagocytosis, and force generation in both prokaryotes and eukaryotes. It is shown that actin has another function in metazoans: patterning biosilica deposition, a role that has spanned over 500 million years. Species of glass sponges (Hexactinellida) and demosponges (Demospongiae), representatives of the first metazoans, with a broad diversity of skeletal structures with hierarchical architecture unchanged since the late Precambrian, are studied. By etching their skeletons, organic templates dominated by individual F-actin filaments, including branched fibers and the longest, thickest actin fiber bundles ever reported, are isolated. It is proposed that these actin-rich filaments are not the primary site of biosilicification, but this highly sophisticated and multi-scale form of biomineralization in metazoans is ptterned.
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hal-03571991 , version 1 (24-10-2022)

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Hermann Ehrlich, Magdalena Luczak, Rustam Ziganshin, Ivan Mikšík, Marcin Wysokowski, et al.. Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges. Advanced Science, 2022, 9 (11), pp.2105059. ⟨10.1002/advs.202105059⟩. ⟨hal-03571991⟩
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