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Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii

Abstract : With a great diversity in gene composition, including multiple putative antibiotic resistance genes, AbaR islands are potential contributors to multidrug resistance in Acinetobacter baumannii . However, the effective contribution of AbaR to antibiotic resistance and bacterial physiology remains elusive. To address this, we sought to accurately remove AbaR islands and restore the integrity of their insertion site. To this end, we devised a versatile scarless genome editing strategy.
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https://hal-cnrs.archives-ouvertes.fr/hal-03548950
Contributor : Samuel Venner Connect in order to contact the contributor
Submitted on : Monday, January 31, 2022 - 10:35:33 AM
Last modification on : Thursday, February 3, 2022 - 3:17:38 AM

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Anne-Sophie Godeux, Elin Svedholm, Agnese Lupo, Marisa Haenni, Samuel Venner, et al.. Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2020, 64 (10), ⟨10.1128/AAC.00951-20⟩. ⟨hal-03548950⟩

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