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Exposure driven risk assessment of nanoparticles: towards a re-equilibration of the traditional "risk = hazard x exposure" equation

Abstract : As of today, the risk assessment associated with nanomaterials and their degradation products is most often addressed in terms of (eco)toxicity of the pristine nano-ingredient embebbed within these materials. Even when acquired properly in terms of doses and characterization efforts, these data barely represent the tip of the iceberg. Such a strategy is ill-adapted to account for the variety of (chemical) situations encountered along the life cycle of a given product and the alterations of the matrix containing the nano-ingredient. Here, we propose to consider exposure to the nano-ingredient as a factor as important as its intrinsic toxicity for the risk assessment of the products in order to implement a safe by design approach. Actual everyday products, such as cosmetics and paints, will serve as examples, as developped in national- (Labex SERENADE) and international projects (Nanoreg, Nanoreg 2, Prosafe, EU-US CoR
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https://hal-cnrs.archives-ouvertes.fr/hal-03547483
Contributor : Armand Masion Connect in order to contact the contributor
Submitted on : Monday, January 31, 2022 - 4:44:06 PM
Last modification on : Wednesday, March 23, 2022 - 3:24:05 PM

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  • HAL Id : hal-03547483, version 1

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A. Masion, C. de Garidel-Thoron, S. Pekar, M. Auffan, J. Rose, et al.. Exposure driven risk assessment of nanoparticles: towards a re-equilibration of the traditional "risk = hazard x exposure" equation. 253rd ACS National Meeting, Apr 2017, San Francisco, CA, United States. ⟨hal-03547483⟩

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