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ACUTE RELEASE OF CATECHOLAMINES ON CIRCULATING BLOOD CELL ADRENOCEPTORS AND METABOLIC INDICES IN DOG

Abstract : The effects of acute release of endogenous catecholamines on both platelet alpha 2 and leukocyte beta adrenoreceptors and metabolic indices (glucose and free fatty acids) were investigated in dogs by means of a model of neurogenic hypertension following acute sinoaortic denervation (ASAD). Despite the marked increase in catecholamine levels (+4.2-fold for noradrenaline and 16.7-fold for adrenaline, for example, at minute 45 following ASAD) and in glucose plasma levels, and the significant decrease in free fatty acid plasma levels, no change in platelet alpha 2 or leukocyte beta adrenoreceptor binding sites (number as well as affinity) was observed during the whole experiment. It is suggested that the number of platelet alpha 2- and leukocyte beta-adrenoreceptors is not submitted to short-term regulation, at least by endogenous catecholamines in dogs.
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https://hal-cnrs.archives-ouvertes.fr/hal-03525745
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Submitted on : Friday, January 14, 2022 - 9:16:56 AM
Last modification on : Wednesday, August 24, 2022 - 4:52:27 PM

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P. Valet, C. Damase-Michel, Mohammed Taouis, J.L. Montastruc, J. Cotonat, et al.. ACUTE RELEASE OF CATECHOLAMINES ON CIRCULATING BLOOD CELL ADRENOCEPTORS AND METABOLIC INDICES IN DOG. Fundamental & Clinical Pharmacology, 1988, 2 (4), pp.267-276. ⟨10.1111/j.1472-8206.1988.tb00638.x⟩. ⟨hal-03525745⟩

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