Direct dynamic readout of molecular chirality with autonomous enzyme driven swimmers - Archive ouverte HAL Access content directly
Journal Articles Nature Chemistry Year : 2021

Direct dynamic readout of molecular chirality with autonomous enzyme driven swimmers

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1
Serena Arnaboldi
Gerardo Salinas
Aleksandar Karajić
Patrick Garrigue
  • Function : Author
Tiziana Benincori
Giorgia Bonetti
  • Function : Author
Roberto Cirilli
Sabrina Bichon
  • Function : Author
Sébastien Gounel
  • Function : Author
Nicolas Mano
Alexander Kuhn
  • Function : Author
  • PersonId : 935442

Abstract

A key approach for designing bioinspired machines is to transfer concepts from nature to man-made structures by integrating biomolecules into artificial mechanical systems. This strategy allows the conversion of molecular information into macroscopic action. Here, we describe the design and dynamic behaviour of hybrid bioelectrochemical swimmers that move spontaneously at the air–water interface. Their motion is governed by the diastereomeric interactions between immobilized enantiopure oligomers and the enantiomers of a chiral probe molecule present in solution. These dynamic bipolar systems are able to convert chiral information present at the molecular level into enantiospecific macroscopic trajectories. Depending on the enantiomer in solution, the swimmers will move clockwise or anticlockwise; the concept can also be used for the direct visualization of the degree of enantiomeric excess by analysing the curvature of the trajectories. Deciphering in such a straightforward way the enantiomeric ratio could be useful for biomedical applications, for the read-out of food quality or as a more general analogue of polarimetric measurements.
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hal-03516122 , version 1 (07-01-2022)

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Serena Arnaboldi, Gerardo Salinas, Aleksandar Karajić, Patrick Garrigue, Tiziana Benincori, et al.. Direct dynamic readout of molecular chirality with autonomous enzyme driven swimmers. Nature Chemistry, 2021, 13 (12), pp.1241-1247. ⟨10.1038/s41557-021-00798-9⟩. ⟨hal-03516122⟩

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