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Health-state utility estimates for health technology assessment: a review of the manufacturers’ submissions to the French National Authority for Health

Abstract : Background: Our aim was to review the selection and methods used for deriving health state utility (HSU) estimates included in the cost-utility analyses (CUA) submitted by manufacturers to the National Authority for Health (HAS) during the first 2years after the introduction of the economic evaluation for price setting in France.Methods: We reviewed all manufacturers' submissions that included a CUA and were assessed by HAS by the end of October 2015 (N=34). We reviewed the identification, selection, and methods used to estimate HSU and compared them with those recommended by HAS.Results: A literature review to identify HSU was reported in only 13 (38%) submissions. The instruments for describing HSU were a preference-based generic instrument in 20 (59%) submissions; vignettes in five (15%); a condition-specific instrument in three (9%); and a combination of instruments in six (18%). The valuation perspective was the general population in 26 (76%) submissions; in only nine (26%) submissions, the valuation set was derived from the French general population.Conclusions: We identified numerous concerns in the selection, valuation and use of HSU, as well as a frequent lack of clarity in the methods used. Most submissions (79%) included HSU that did not meet HAS recommendations.
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https://hal-cnrs.archives-ouvertes.fr/hal-03479968
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Submitted on : Tuesday, December 14, 2021 - 3:14:48 PM
Last modification on : Friday, January 7, 2022 - 3:45:45 AM

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Ff Hamers, S Ghabri, Catherine Le Galès. Health-state utility estimates for health technology assessment: a review of the manufacturers’ submissions to the French National Authority for Health. Expert Review of Pharmacoeconomics and Outcomes Research, Expert Reviews, 2017, 17 (5), pp.489-494. ⟨10.1080/14737167.2017.1289088⟩. ⟨hal-03479968⟩

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