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Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism

Abstract : A variable (GT)n repeat in the 5′-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject–control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10−4). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.
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https://hal-cnrs.archives-ouvertes.fr/hal-03478559
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Submitted on : Tuesday, December 14, 2021 - 8:39:15 AM
Last modification on : Tuesday, October 18, 2022 - 4:29:46 AM

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M-C Domart, A Benyamina, A Lemoine, Catherine Bourgain, L Blecha, et al.. Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism. Addiction Biology, 2012, 17 (4), pp.783-785. ⟨10.1111/j.1369-1600.2011.00321.x⟩. ⟨hal-03478559⟩

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