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Deregulation of Slug/Snail2 and TGF-β crosstalk in airway epithelial stem/progenitor cells: A key link between COPD and lung cancer?

Abstract : This commentary focuses on two recent publications showing deregulation of the transcription factor Slug/Snail2 and TGF-β function in primary bronchial basal/progenitor cells of patients with Chronic Obstructive Pulmonary Disease (COPD) and the impact on proliferation and the expression of genes involved in stem cell maintenance. We discuss the molecular mechanisms related to the exhaustion of airway basal stem/ progenitor cells in tobacco smoke-induced COPD, as well as putative links between COPD and lung cancer at the molecular level. The focus of the commentary is a potential central role of the crosstalk between Slug/Snail2 and TGF-β signaling mechanisms, and perspectives for identification of new biomarkers and/or therapeutic targets or therapy for preventing and treating these diseases.
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Journal articles
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https://hal-cnrs.archives-ouvertes.fr/hal-03476323
Contributor : Pascale Leroy Connect in order to contact the contributor
Submitted on : Monday, January 3, 2022 - 5:05:22 PM
Last modification on : Thursday, January 6, 2022 - 3:46:56 AM

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Distributed under a Creative Commons Attribution 4.0 International License

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  • HAL Id : hal-03476323, version 1

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Pascale Leroy. Deregulation of Slug/Snail2 and TGF-β crosstalk in airway epithelial stem/progenitor cells: A key link between COPD and lung cancer?. Archives of stem cell and therapy, ProBiologists LLC, In press. ⟨hal-03476323⟩

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