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3NeuroPSI - Institut des Neurosciences Paris-Saclay (Centre National de la Recherche Scientifique, Unité Mixte de Recherche-9197 Université Paris-Saclay
Campus CEA Saclay, Bât. 151
151 route de la Rotonde
91400 Saclay - France)
Université Paris-Saclay (Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette - France)
Abstract : We explored here the hypothesis that temporary chronic water restriction in mice affects social behavior, via its action on the density of 5-HT neurons in dorsal and median raphe nuclei (DRN and MRN). For that, we submitted adult C57BL/6J mice to mild and controlled temporary dehydration, i.e., 6h of water access every 48h for 15 days. We investigated their social behavior in a social interaction task known to allow free and reciprocal social contact and to rely on prefrontal cortex activity and monoaminergic prefrontal input. Results showed that temporary dehydration increases significantly time spent in social contact and social dominance. It also expands 5-HT neuron density within both DRN and MRN and the behavioral and neuronal plasticity were positively correlated. Our findings suggest that disturbance in 5-HT innervation caused by temporary dehydratation stress unbalances choice processes of animals in social context.
https://hal-cnrs.archives-ouvertes.fr/hal-03452677 Contributor : Anne NosjeanConnect in order to contact the contributor Submitted on : Saturday, November 27, 2021 - 11:27:10 AM Last modification on : Sunday, June 26, 2022 - 3:21:49 AM Long-term archiving on: : Monday, February 28, 2022 - 6:18:18 PM
Houari Boukersi, Nemcha Lebaili, Anne Nosjean, Nathalie Samson, Alexis Faure, et al.. Effect of water restriction stress on social behavior in mice: Impact on serotonergic system plasticity. Behavioural Brain Research, Elsevier, 2021, 399:, pp.113022. ⟨10.1016/j.bbr.2020.113022⟩. ⟨hal-03452677⟩