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DNA-Controlled Spatiotemporal Patterning of a Cytoskeletal Active Gel

Abstract : Living cells move and change their shape because signaling chemical reactions modify the state of their cyto-skeleton; an active gel that converts chemical energy into mechanical forces. To create lifelike materials, it is thus key to engineer chemical pathways that drive active gels. Here, we describe the preparation of DNA-responsive surfaces that control the activity of a cytoskeletal active gel comprised of microtubules: a DNA signal triggers the release of molecular motors from the surface into the gel bulk, generating forces that structure the gel. Depending on the DNA sequence and concentration , the gel forms a periodic band pattern or contracts globally. Finally, we show that the structuration of the active gel can be spatially controlled in the presence of a gradient of DNA concentration. We anticipate that such DNA-controlled active matter will contribute to the development of lifelike materials with self-shaping properties.
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https://hal-cnrs.archives-ouvertes.fr/hal-03451234
Contributor : Andre Estevez-Torres Connect in order to contact the contributor
Submitted on : Friday, November 26, 2021 - 1:04:02 PM
Last modification on : Monday, October 10, 2022 - 11:11:15 AM
Long-term archiving on: : Sunday, February 27, 2022 - 7:07:51 PM

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Yuliia Vyborna, Jean-Christophe Galas, André Estevez-Torres. DNA-Controlled Spatiotemporal Patterning of a Cytoskeletal Active Gel. Journal of the American Chemical Society, 2021, ⟨10.1021/jacs.1c06730⟩. ⟨hal-03451234⟩

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