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Short-Term Plasticity Combines with Excitation–Inhibition Balance to Expand Cerebellar Purkinje Cell Dynamic Range

Abstract : The balance between excitation (E) and inhibition (I) in neuronal networks controls the firing rate of principal cells through simple network organization, such as feedforward inhibitory circuits. Here, we demonstrate in male mice, that at the granule cell (GrC)molecular layer interneuron (MLI)-Purkinje cell (PC) pathway of the cerebellar cortex, E/I balance is dynamically controlled by shortterm dynamics during bursts of stimuli, shaping cerebellar output. Using a combination of electrophysiological recordings, optogenetic stimulation, and modeling, we describe the wide range of bidirectional changes in PC discharge triggered by GrC bursts, from robust excitation to complete inhibition. At high frequency (200 Hz), increasing the number of pulses in a burst (from 3 to 7) can switch a net inhibition of PC to a net excitation. Measurements of EPSCs and IPSCs during bursts and modeling showed that this feature can be explained by the interplay between short-term dynamics of the GrC-MLI-PC pathway and E/I balance impinging on PC. Our findings demonstrate that PC firing rate is highly sensitive to the duration of GrC bursts, which may define a temporal-to-rate code transformation in the cerebellar cortex.
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https://hal-cnrs.archives-ouvertes.fr/hal-03430439
Contributor : Philippe Isope Connect in order to contact the contributor
Submitted on : Tuesday, November 16, 2021 - 11:34:43 AM
Last modification on : Wednesday, February 16, 2022 - 2:22:02 PM
Long-term archiving on: : Thursday, February 17, 2022 - 6:36:09 PM

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Anais Grangeray-Vilmint, Antoine M Valera, Arvind Kumar, Philippe Isope. Short-Term Plasticity Combines with Excitation–Inhibition Balance to Expand Cerebellar Purkinje Cell Dynamic Range. Journal of Neuroscience, Society for Neuroscience, 2018, 38 (22), pp.5153-5167. ⟨10.1523/JNEUROSCI.3270-17.2018⟩. ⟨hal-03430439⟩

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