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PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory

Abstract : Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2 MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.
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Contributor : Jean-Michel Revest Connect in order to contact the contributor
Submitted on : Wednesday, November 10, 2021 - 3:10:56 PM
Last modification on : Friday, January 14, 2022 - 9:26:02 AM


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C Bouarab, V Roullot-Lacarrière, M Vallée, A Le Roux, C Guette, et al.. PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory. Molecular Psychiatry, Nature Publishing Group, 2021, ⟨10.1038/s41380-021-01024-1⟩. ⟨hal-03424451⟩



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