PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory - Archive ouverte HAL Access content directly
Journal Articles Molecular Psychiatry Year : 2021

PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory

(1) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1)
1

Abstract

Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2 MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.
Fichier principal
Vignette du fichier
Bouarab-Lacarriere-SuppInfo_MolPsy 2021.pdf (2.79 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03424451 , version 1 (10-11-2021)

Identifiers

Cite

C Bouarab, V Roullot-Lacarrière, M Vallée, A Le Roux, C Guette, et al.. PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory. Molecular Psychiatry, 2021, ⟨10.1038/s41380-021-01024-1⟩. ⟨hal-03424451⟩
14 View
20 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More