Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia

Tra Ly Nguyen , Marie‐julie Nokin , Silvia Terés , Mercedes Tomé , Clément Bodineau , Oriane Galmar , Jean‐max Pasquet , Benoit Rousseau , Sebastian Liempd , Juan Manuel Falcon‐perez , Elodie Richard , Elodie Muzotte , Hamid‐reza Rezvani , Muriel Priault (1) , Marion Bouchecareilh , Isabelle Redonnet‐vernhet , Julien Calvo , Benjamin Uzan , Françoise Pflumio , Patricia Fuentes , Maria Toribio , Abdel‐majid Khatib , Pierre Soubeyran , Piedad del Socorro Murdoch , Raúl Durán

1 CNRS - Centre National de la Recherche Scientifique

Domains: Life Sciences [q-bio]; Cellular Biology; Subcellular Processes [q-bio.SC]; Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Molecular biology

Tra Ly Nguyen, Marie‐julie Nokin, Silvia Terés, Mercedes Tomé, Clément Bodineau, et al.. Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia. Molecular Oncology, 2021, 15 (5), pp.1412-1431. ⟨10.1002/1878-0261.12877⟩. ⟨hal-03401225⟩