Reactive astrocyte nomenclature, definitions, and future directions - Archive ouverte HAL Access content directly
Journal Articles Nature Neuroscience Year : 2021

Reactive astrocyte nomenclature, definitions, and future directions

(1) , (2, 3) , (4) , (5) , (6, 7) , (8, 7) , (9) , (10) , (11, 12) , (13) , (14) , (15) , (16) , (17) , (18) , (1) , (19) , (20) , (21) , (22) , (23) , (20, 24) , (25) , (26) , (27) , (28) , (29) , (30, 31) , (32, 33) , (34, 35) , (36) , (37) , (38) , (20) , (39) , , (40) , (41) , (42) , (43) , (44) , (45) , (46, 10) , (47) , (48) , (49) , (50) , (51) , (52) , (53) , (54, 55, 56) , (53) , (57) , (58) , (58) , (59) , (60) , (61) , (62) , (49) , (63) , (64) , (1) , , (65) , (18) , (21) , , (66, 67) , (68, 69) , , (49) , (35, 70) , (41) , (71) , (72) , (73) , (74) , (75) , (76) , (77, 78)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
Carole Escartin
András Lakatos
Alfonso Araque
Luis Barbeito
Ari Barzilai
  • Function : Author
Gilles Bonvento
Arthur Butt
Benjamin Deneen
Cinthia Farina
Marc Freeman
  • Function : Author
Vittorio Gallo
Dieter Heiland
Elly Hol
Ksenia Kastanenka
  • Function : Author
Schuichi Koizumi
Brian Macvicar
Anna Molofsky
Seiji Okada
Marcela Pekna
Gertrudis Perea
Stefanie Robel
  • Function : Author
David Rowitch
Harald Sontheimer
Robert Zorec

Abstract

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.

Dates and versions

hal-03372664 , version 1 (11-10-2021)

Identifiers

Cite

Carole Escartin, Elena Galea, András Lakatos, James O’callaghan, Gabor Petzold, et al.. Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience, 2021, 24 (3), pp.312-325. ⟨10.1038/s41593-020-00783-4⟩. ⟨hal-03372664⟩
48 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More