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Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin 1 Elena Galea 2, 3 András Lakatos 4 James O’callaghan 5 Gabor Petzold 6, 7 Alberto Serrano-Pozo 8, 7 Christian Steinhäuser 9 Andrea Volterra 10 Giorgio Carmignoto 11, 12 Amit Agarwal 13 Nicola Allen 14 Alfonso Araque 15 Luis Barbeito 16 Ari Barzilai 17 Dwight Bergles 18 Gilles Bonvento 1 Arthur Butt 19 Wei-Ting Chen 20 Martine Cohen-Salmon 21 Colm Cunningham 22 Benjamin Deneen 23 Bart de Strooper 20, 24 Blanca Díaz-Castro 25 Cinthia Farina 26 Marc Freeman 27 Vittorio Gallo 28 James Goldman 29 Steven Goldman 30, 31 Magdalena Götz 32, 33 Antonia Gutiérrez 34, 35 Philip Haydon 36 Dieter Heiland 37 Elly Hol 38 Matthew Holt 39 Masamitsu Iino 40 Ksenia Kastanenka Helmut Kettenmann 41 Baljit Khakh 42 Schuichi Koizumi 43 C. Justin Lee 44 Shane Liddelow 45 Brian Macvicar 46 Pierre Magistretti 47, 10 Albee Messing 48 Anusha Mishra 49 Anna Molofsky 50 Keith Murai 51 Christopher Norris 52 Seiji Okada 53 Stéphane Oliet 54 João Oliveira 55, 56, 57 Aude Panatier 54 Vladimir Parpura 58 Marcela Pekna 59 Milos Pekny 59 Luc Pellerin 60 Gertrudis Perea 61 Beatriz Pérez-Nievas 62 Frank Pfrieger 63 Kira Poskanzer 50 Francisco Quintana 64 Richard Ransohoff 65 Miriam Riquelme-Perez 1 Stefanie Robel Christine Rose 66 Jeffrey Rothstein 18 Nathalie Rouach 21 David Rowitch Alexey Semyanov 67, 68 Swetlana Sirko 69, 70 Harald Sontheimer Raymond Swanson 50 Javier Vitorica 35, 71 Ina-Beate Wanner 42 Levi Wood 72 Jiaqian Wu 73 Binhai Zheng 74 Eduardo Zimmer 75 Robert Zorec 76 Michael Sofroniew 77 Alexei Verkhratsky 78, 79
Abstract : Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.
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https://hal-cnrs.archives-ouvertes.fr/hal-03372664
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Submitted on : Monday, October 11, 2021 - 8:45:35 AM
Last modification on : Wednesday, October 20, 2021 - 3:22:20 AM

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Carole Escartin, Elena Galea, András Lakatos, James O’callaghan, Gabor Petzold, et al.. Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience, Nature Publishing Group, 2021, 24 (3), pp.312-325. ⟨10.1038/s41593-020-00783-4⟩. ⟨hal-03372664⟩

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