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Assessment of the SpO2/FiO2 ratio as a tool for hypoxemia screening in the emergency department

Abstract : We assessed the performance of the ratio of peripheral arterial oxygen saturation to the inspired fraction of oxygen (SpO 2 /FiO 2) to predict the ratio of partial pressure arterial oxygen to the fraction of inspired oxygen (PaO 2 /FiO 2) among patients admitted to our emergency department (ED) during the SARS-CoV-2 outbreak. Methods: We retrospectively studied patients admitted to an academic-level ED in France who were undergoing a joint measurement of SpO 2 and arterial blood gas. We compared SpO 2 with SaO 2 and evaluated performance of the SpO 2 /FiO 2 ratio for the prediction of 300 and 400 mmHg PaO 2 /FiO 2 cutoff values in COVID-19 positive and negative subgroups using receiver-operating characteristic (ROC) curves. Results: During the study period from February to April 2020, a total of 430 arterial samples were analyzed and collected from 395 patients. The area under the ROC curves of the SpO 2 /FiO 2 ratio was 0.918 (CI 95% 0.885-0.950) and 0.901 (CI 95% 0.872-0.930) for PaO 2 /FiO 2 thresholds of 300 and 400 mmHg, respectively. The positive predictive value (PPV) of an SpO 2 /FiO 2 threshold of 350 for PaO 2 /FiO 2 inferior to 300 mmHg was 0.88 (CI95% 0.84-0.91), whereas the negative predictive value (NPV) of the SpO 2 /FiO 2 threshold of 470 for PaO 2 /FiO 2 inferior to 400 mmHg was 0.89 (CI95% 0.75-0.96). No significant differences were found between the subgroups. Conclusions: The SpO 2 /FiO 2 ratio may be a reliable tool for hypoxemia screening among patients admitted to the ED, particularly during the SARS-CoV-2 outbreak.
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https://hal-cnrs.archives-ouvertes.fr/hal-03366071
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Submitted on : Wednesday, October 6, 2021 - 3:47:28 PM
Last modification on : Friday, April 1, 2022 - 3:49:50 AM

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Pierre Catoire, Eric Tellier, Caroline de la Rivière, Marie-Christine Beauvieux, Guillaume Valdenaire, et al.. Assessment of the SpO2/FiO2 ratio as a tool for hypoxemia screening in the emergency department. American Journal of Emergency Medicine, Elsevier, 2021, 44, pp.116-120. ⟨10.1016/j.ajem.2021.01.092⟩. ⟨hal-03366071⟩

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