Skip to Main content Skip to Navigation
Journal articles

Disrupted function of lactate transporter MCT1 , but not MCT4 , in Schwann cells affects the maintenance of motor end‐plate innervation

Abstract : Recent studies in neuron-glial metabolic coupling have shown that, in the CNS, astrocytes and oligodendrocytes support neurons with energy-rich lactate/pyruvate via monocarboxylate transporters (MCTs). The presence of such transporters in the PNS, in both Schwann cells and neurons, has prompted us to question if a similar interaction may be present. Here we describe the generation and characterization of conditional knockout mouse models where MCT1 or MCT4 is specifically deleted in Schwann cells (named MCT1 and MCT4 cKO). We show that MCT1 cKO and MCT4 cKO mice develop normally and that myelin in the PNS is preserved. However, MCT1 expressed by Schwann cells is necessary for long-term maintenance of motor end-plate integrity as revealed by disrupted neuromuscular innervation in mutant mice, while MCT4 appears largely dispensable for the support of motor neurons.
Document type :
Journal articles
Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03366045
Contributor : Karine Viaud Connect in order to contact the contributor
Submitted on : Tuesday, October 5, 2021 - 2:51:43 PM
Last modification on : Wednesday, October 6, 2021 - 4:48:28 PM

File

Bouçanova et al. - 2021 - Di...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Filipa Bouçanova, Gill Pollmeier, Katalin Sandor, Carlos Morado Urbina, Jik Nijssen, et al.. Disrupted function of lactate transporter MCT1 , but not MCT4 , in Schwann cells affects the maintenance of motor end‐plate innervation. Glia, Wiley, 2021, 69 (1), pp.124-136. ⟨10.1002/glia.23889⟩. ⟨hal-03366045⟩

Share

Metrics

Record views

6

Files downloads

4