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Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?

Abstract : Neurons within the arcuate nucleus control energy balance and represent the functional substrates through which FGF1 deploys its anti-diabetic action. Alonge et al. (2020) now report that the integrity of arcuate peri-neuronal nets, an extracellular matrix component that enmeshes GABAergic neurons, is reversibly altered in diabetic rats and a key component for FGF1-mediated diabetic remission. These novel insights unravel how perineuronal nets dynamically contribute to the central control of glycemia.
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https://hal-cnrs.archives-ouvertes.fr/hal-03300404
Contributor : Colette Orange <>
Submitted on : Tuesday, July 27, 2021 - 10:14:38 AM
Last modification on : Thursday, July 29, 2021 - 3:18:44 AM

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Giuseppe Gangarossa, Serge Luquet. Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?. Cell Metabolism, Elsevier, 2020, 32 (5), pp.701-703. ⟨10.1016/j.cmet.2020.10.003⟩. ⟨hal-03300404⟩

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