Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?

Giuseppe Gangarossa (1) , Serge Luquet (1)

1 BFA (UMR_8251 / U1133) - Unité de Biologie Fonctionnelle et Adaptative

Neurons within the arcuate nucleus control energy balance and represent the functional substrates through which FGF1 deploys its anti-diabetic action. Alonge et al., (2020) now reports that the integrity of arcuate perineuronal nets, an extracellular matrix component that enmesh GABAergic neurons, is reversibly altered in diabetic rats, and a key component for FGF1-mediated diabetic remission. These novel insights unravel how perineuronal nets dynamically contribute to the central control of glycemia.

Domaines: Sciences du Vivant [q-bio]

Giuseppe Gangarossa, Serge Luquet. Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?. Cell Metabolism, 2020, 32 (5), pp.701 - 703. ⟨10.1016/j.cmet.2020.10.003⟩. ⟨hal-03372048⟩