Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins - Archive ouverte HAL Access content directly
Book Sections Year : 2018

Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins

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Abstract

Very few discoveries in the neurosciences have triggered clinical speculation and experimentation regarding the etiology of psychiatric illness to the same extent as that following identification of the opiate receptor(s) and subsequent isolation of endogenous morphine-like peptides. There is overwhelming evidence in animals and in human that opioids are involved in behaviorally relevant issues such as the modulation of pain, the response to stress, motivation, addiction, sexuality, food intake, etc., but our knowledge on the possible relation between opioids and mental illness is still very limited. These responses could be explored either by using highly selective delta agonist or by emphasizing the effects of phasically secreted endogenous opioid peptides, enkephalin. Both approaches were investigated in particular through protection of enkephalin degradation by dual enkephalinase inhibitors DENKIs such as RB101, PL37 or PL265
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Dates and versions

hal-03294135 , version 1 (21-07-2021)

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Bernard P Roques. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins. Delta Opioid Receptor Pharmacology and Therapeutic Applications, 247, pp.53-70, 2018, Handbook of Experimental Pharmacology, ⟨10.1007/164_2016_17⟩. ⟨hal-03294135⟩
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