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In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice

Abstract : Regional cerebral atrophy was evaluated in APP/PS1 mice harboring mutated transgenes linked to familial Alzheimer's disease, using complementary methods. In vivo high resolution MRI was selected for measurements of brain atrophy and associated cerebrospinal fluid dilation; histological analysis was performed to reveal localized atrophies and to evaluate amyloid burden. Young APP/PS1 mice examined at a pre-amyloid stage (10 weeks) showed disruption in development (reduced intracranial and brain volumes). Comparison of young and old (24 months) mice, indicated that both APP/PS1 and control brains endure growth during adulthood. Aged APP/PS1 animals showed a moderate although significant global brain atrophy and a dilation of CSF space in posterior brain regions. The locus of this atrophy was identified in the midbrain area and not, as expected, at isocortical/hippocampal levels. Atrophy was also detected in fiber tracts. The severity of brain atrophy in old APP/PS1 mice was not correlated with the extent of cerebral amyloidosis. The relevance of current transgenic mouse models for the study of brain atrophy related to Alzheimer's disease is discussed.
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https://hal-cnrs.archives-ouvertes.fr/hal-03236868
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Submitted on : Wednesday, May 26, 2021 - 3:03:18 PM
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B. Delatour, Maryvonne Guégan, Andreas Volk, Marc Dhenain. In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice. Neurobiol Aging, 2006, 27 (6), pp.835-47. ⟨10.1016/j.neurobiolaging.2005.04.011⟩. ⟨hal-03236868⟩

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