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Journal Articles Antioxidants and Redox Signaling Year : 2019

Physical and Functional Cross Talk Between Endo-Sarcoplasmic Reticulum and Mitochondria in Skeletal Muscle

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Simona Boncompagni
  • Function : Author
Diego Pozzer
  • Function : Author
Carlo Viscomi
  • Function : Author
Ester Zito
  • Function : Author

Abstract

Recent Advances: An extensive close proximity of these two organelles is a late developmental event, which suggests that it does not have an essential function. Critical Issues: The intimate association of SR/mitochondria develops during murine postnatal differentiation and the recovery of denervated atrophic muscle, which suggests that this is a highly regulated process with a specific function. Analyses of mouse models for muscle diseases suggest that impaired ER/SR-mitochondrial contacts may be due to ER stress and lead to defective bioenergetics and insulin signaling. Future Directions: Future studies are necessary to identify the molecular determinants weakening insulin signaling upon impairment of ER/mitochondrial contacts in skeletal muscles as well as to analyze the distance between SR/ER and mitochondria in muscle diseases associated with ER stress.
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Dates and versions

hal-03201558 , version 1 (19-04-2021)

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Simona Boncompagni, Diego Pozzer, Carlo Viscomi, Ana Ferreiro, Ester Zito. Physical and Functional Cross Talk Between Endo-Sarcoplasmic Reticulum and Mitochondria in Skeletal Muscle. Antioxidants and Redox Signaling, 2019, 32 (12), pp.873-883. ⟨10.1089/ars.2019.7934⟩. ⟨hal-03201558⟩
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