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Physical and Functional Cross Talk Between Endo-Sarcoplasmic Reticulum and Mitochondria in Skeletal Muscle

Abstract : Recent Advances: An extensive close proximity of these two organelles is a late developmental event, which suggests that it does not have an essential function. Critical Issues: The intimate association of SR/mitochondria develops during murine postnatal differentiation and the recovery of denervated atrophic muscle, which suggests that this is a highly regulated process with a specific function. Analyses of mouse models for muscle diseases suggest that impaired ER/SR-mitochondrial contacts may be due to ER stress and lead to defective bioenergetics and insulin signaling. Future Directions: Future studies are necessary to identify the molecular determinants weakening insulin signaling upon impairment of ER/mitochondrial contacts in skeletal muscles as well as to analyze the distance between SR/ER and mitochondria in muscle diseases associated with ER stress.
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https://hal-cnrs.archives-ouvertes.fr/hal-03201558
Contributor : Colette Orange <>
Submitted on : Monday, April 19, 2021 - 8:57:36 AM
Last modification on : Wednesday, April 21, 2021 - 3:23:35 AM

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Simona Boncompagni, Diego Pozzer, Carlo Viscomi, Ana Ferreiro, Ester Zito. Physical and Functional Cross Talk Between Endo-Sarcoplasmic Reticulum and Mitochondria in Skeletal Muscle. Antioxidants and Redox Signaling, Mary Ann Liebert, 2019, 32 (12), pp.873-883. ⟨10.1089/ars.2019.7934⟩. ⟨hal-03201558⟩

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