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PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory
Abstract : Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.
https://hal-cnrs.archives-ouvertes.fr/hal-03132810
Contributor : Jean-Michel Revest Connect in order to contact the contributor
Submitted on : Friday, February 5, 2021 - 1:58:03 PM
Last modification on : Friday, February 5, 2021 - 1:58:04 PM
Contributor : Jean-Michel Revest Connect in order to contact the contributor
Submitted on : Friday, February 5, 2021 - 1:58:03 PM
Last modification on : Friday, February 5, 2021 - 1:58:04 PM
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