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The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis

Abstract : GATA transcription factors and their FOG cofactors play a key role in tissue-specific development and differentiation, from worms to humans. Mammals have six GATA and two FOG factors. We recently demonstrated that interactions between retinoblastoma protein (pRb) and GATA-1 are crucial for erythroid proliferation and differentiation. We show here that the LXCXE pRb-binding site of FOG-2 is involved in adipogenesis. Unlike GATA-1, which inhibits cell division, FOG-2 promotes proliferation. Mice with a knockin of a Fog2 gene bearing a mutated LXCXE pRb-binding site are resistant to obesity and display higher rates of white-to-brown fat conversion. Thus, each component of the GATA/FOG complex (GATA-1 and FOG-2) is involved in pRb/E2F regulation, but these molecules have markedly different roles in the control of tissue homeostasis.
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https://hal-cnrs.archives-ouvertes.fr/hal-03108274
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Submitted on : Wednesday, January 13, 2021 - 9:43:53 AM
Last modification on : Wednesday, July 28, 2021 - 9:57:58 AM

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O Goupille, T Penglong, Z Kadri, M Granger-Locatelli, R Denis, et al.. The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis. Cell Reports, Elsevier Inc, 2017, 21 (12), pp.3524-3535. ⟨10.1016/j.celrep.2017.11.098⟩. ⟨hal-03108274⟩

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