Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality?

C Herbemont , S Sarandi , J Boujenah , I Cedrin-Durnerin , N Sermondade , A Vivot (1) , C Poncelet , M Grynberg (2) , C Sifer

1 CRESS - U1153 - Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques
2 BFA (UMR_8251 / U1133) - Unité de Biologie Fonctionnelle et Adaptative

Clinical outcomes of 291 day-5 blastocyst transfers carried out between January 2012 and March 2016 were retrospectively compared according to their quality at day 2 and 3. Inclusion criteria were female age younger than 37 years; first or second IVF and intracytoplasmic sperm injection cycle; quality of the transferred blastocyst: blastocoele B3 or higher; inner-cell-mass A/B; trophectoderm A/B; and known implantation outcome for each transferred blastocyst. Blastocysts were classified into good-quality and poor-quality embryo groups at day 2 and 3. Implantation (38.7% versus 41.4), clinical pregnancy (40.3% versus 45.9%), miscarriage (22.2% versus 26.7%;) and live birth rates (37.4% versus 38.8%) were comparable in day 2 good and poor-quality embryo groups. No signficiant differences in morphology of transferred blastocysts at day 3 were found. Multivariable analysis highlighted that poor or good embryo quality at day 2 and day 3 were not predictive of the implantation of good-quality blastocysts (at day 2: adjusted odds ratio = 0.82 CI 95% 0.49 to 1.38; at day 3: adjusted odds ratio = 1.39; CI 95% 0.77 to 2.52). Good-quality blastocyst transfer should, therefore, be carried out irrespective of embryo quality at cleavage stage, as it may not compromise success rates in a good-prognosis population. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Keywords: STAGE EMBRYOS; CLEAVAGE; TIME; MULTICENTER; CYCLES; INTEROBSERVER; SELECTION

Domains: Life Sciences [q-bio]

C Herbemont, S Sarandi, J Boujenah, I Cedrin-Durnerin, N Sermondade, et al.. Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality?. Reproductive BioMedicine Online, 2017, 35 (5), pp.521-528. ⟨10.1016/j.rbmo.2017.07.014⟩. ⟨hal-03108255⟩