Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality? - Archive ouverte HAL Access content directly
Journal Articles Reproductive BioMedicine Online Year : 2017

Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality?

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C Herbemont
  • Function : Author
S Sarandi
  • Function : Author
J Boujenah
  • Function : Author
I Cedrin-Durnerin
  • Function : Author
N Sermondade
  • Function : Author
C Poncelet
  • Function : Author
C Sifer
  • Function : Author

Abstract

Clinical outcomes of 291 day-5 blastocyst transfers carried out between January 2012 and March 2016 were retrospectively compared according to their quality at day 2 and 3. Inclusion criteria were female age younger than 37 years; first or second IVF and intracytoplasmic sperm injection cycle; quality of the transferred blastocyst: blastocoele B3 or higher; inner-cell-mass A/B; trophectoderm A/B; and known implantation outcome for each transferred blastocyst. Blastocysts were classified into good-quality and poor-quality embryo groups at day 2 and 3. Implantation (38.7% versus 41.4), clinical pregnancy (40.3% versus 45.9%), miscarriage (22.2% versus 26.7%;) and live birth rates (37.4% versus 38.8%) were comparable in day 2 good and poor-quality embryo groups. No signficiant differences in morphology of transferred blastocysts at day 3 were found. Multivariable analysis highlighted that poor or good embryo quality at day 2 and day 3 were not predictive of the implantation of good-quality blastocysts (at day 2: adjusted odds ratio = 0.82 CI 95% 0.49 to 1.38; at day 3: adjusted odds ratio = 1.39; CI 95% 0.77 to 2.52). Good-quality blastocyst transfer should, therefore, be carried out irrespective of embryo quality at cleavage stage, as it may not compromise success rates in a good-prognosis population. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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hal-03108255 , version 1 (17-11-2022)

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C Herbemont, S Sarandi, J Boujenah, I Cedrin-Durnerin, N Sermondade, et al.. Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality?. Reproductive BioMedicine Online, 2017, 35 (5), pp.521-528. ⟨10.1016/j.rbmo.2017.07.014⟩. ⟨hal-03108255⟩
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